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ISSN: 2957-5443
Indexed in: OAJ, Europub, Crossref, Dimensions, Google Scholar
Editor-in-Chief: Lize XIONG
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Volume 4, Issue 1
Dysregulated cell death and inflammation in Perioperative Medicine: Mechanisms and therapeutic opportunities

Review Article |Published on: 31 March 2026

[Perioperative Precision Medicine] 2026; 4 (1): 1-43.

DOI: https://doi.org/10.61189/775612vwvmhm
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Mechanisms of traditional Chinese medicine extracts in ameliorating sepsis-induced myocardial injury

Yutong Sun1,2,3,*, Qin Zhang1,3,*, Yan Zhang2,3,4,*, Sixu Chen2,3,4, Jiayin Wang3,5, Weiqi Lin1,3, Haiyi Qian3,5, Xinyi Xie3,5, Qixiang Xu3,5, Xiaolong Yuan6, Cuifeng Zhang2,3,4 


1School of Clinical Medicine, Wannan Medical College, Wuhu 241002, Anhui, China. 

2Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China. 

3Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu 241002, Anhui, China. 

4School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China. 

5School of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China. 

6The Second Affiliated Hospital of Wannan Medical College, Wuhu 241002, Anhui, China. 

*The authors contribute equally and co-first authors.


Address correspondence to: Cuifeng Zhang, School of Anesthesiology, Wannan Medical College, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel: +86-15551257181. E-mail: zhangcuifeng@wnmc.edu.cn.


DOI: https://doi.org/10.61189/873111rbsjxe


Received September 5, 2025; Accepted March 3, 2026; Published March 31, 2026 


Highlights 

● This review presents a comprehensive overview of the pharmacological effects of traditional Chinese medicine (TCM) in sepsisinduced myocardial injury. 

● It systematically summarizes the molecular mechanisms and recent research advancements regarding protective effects of TCM in sepsis. 

● It proposes a novel "temporal treatment" strategy for Perioperative Sepsis, aligning TCM interventions with the dynamic pathophysiological stages of the disease.

Review Article |Published on: 31 March 2026

[Perioperative Precision Medicine] 2026; 4 (1): 71-93

DOI: https://doi.org/10.61189/873111rbsjxe
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Elevated red cell distribution width opon ICU admission independently predicts mortality in young patients with sepsis-associated encephalopathy: A propensity score-matched retrospective cohort study using MIMIC-IV database

Yalin Zhu1,2,*, Zhengyu Jiang2,*, Wangzheqi Zhang2,3,*, Jie Huang2, Haoling Zhang4, Haiwen Wang1, Jiafeng Wang2,#, Wen Xu1,# 


1Department of Anesthesiology, Naval Hospital of Eastern Theater, Zhoushan 316004, Zhejiang, China. 

2Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. 

3School of Anesthesiology, Naval Medical University, Shanghai 200433, China. 

4Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang, Malaysia. 

*The authors contribute equally. 

#The authors are co-corresponding authors.


Address correspondence to: Wen Xu, Department of Anesthesiology, Naval Hospital of Eastern Theater, No. 98, Wenhua Road, Dinghai District, Zhoushan 316004, Zhejiang, China. E-mail: xuwennhet@163.com. Jiafeng Wang, Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, No. 168, Changhai Road, Yangpu District, Shanghai 200433, China. E-mail: jfwang@smmu.edu.cn.


DOI: https://doi.org/10.61189/402108pvrojs


Received November 18, 2025; Accepted March 3, 2026; Published March 31, 2026


Highlights 

● Elevated red cell distribution width (RDW) (>14.65%) at intensive care unit admission independently predicts 30-day mortality in young patients with sepsis-associated encephalopathy (SAE) (hazard ratio=2.7, 95% confidence interval [CI]: 1.4-5.3; P=0.003), persisting after rigorous propensity score matching (352 pairs) and multivariable adjustment. 

● RDW achieved an area under the curve of 0.760 (95% CI: 0.720-0.800), outperforming prior reports in elderly sepsis cohorts and underscoring its specificity for young SAE.

● RDW is a low-cost, routinely available biomarker. Its integration into risk stratification could enable early intervention in resourcelimited settings, challenging the paradigm of youth conferring low risk in SAE.

Research Article |Published on: 31 March 2026

[Perioperative Precision Medicine] 2026; 4 (1): 94-104

DOI: https://doi.org/10.61189/402108pvrojs
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The future of minimally invasive surgery: A revolutionary new chapter in medicine

Perspective |Published on: 31 March 2026

[Perioperative Precision Medicine] 2026; 4 (1): 105-109

DOI: https://doi.org/10.61189/189238vryaia
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Expert opinion on perioperative management of bleeding and coagulation in anesthesiology (2026 edition)

Expert Consensus |Published on: 31 March 2026

[Perioperative Precision Medicine] 2026; 4 (1): 110-129

DOI: https://doi.org/10.61189/909222ormctb
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