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20180041@wnmc.edc.cnLipid metabolism and iron metabolism pathways are key biological pathways involved in ferroptosis.
Ferroptosis exhibits complex crosstalk with other cell death forms in sepsis, with significant implications for disease pathogenesis and therapy.
Ferroptosis plays a critical role in sepsis-related organ damage and prognosis.
This review suggests directions and perspectives for treating ferroptosis and sepsis in the perioperative period.
Open Access20180041@wnmc.edc.cnLipid metabolism and iron metabolism pathways are key biological pathways involved in ferroptosis.
Ferroptosis exhibits complex crosstalk with other cell death forms in sepsis, with significant implications for disease pathogenesis and therapy.
Ferroptosis plays a critical role in sepsis-related organ damage and prognosis.
This review suggests directions and perspectives for treating ferroptosis and sepsis in the perioperative period.
Ferroptosis is a newly identified form of cell death that has garnered attention in recent years. Current research has clarified several key mechanisms of ferroptosis, with reactive oxygen species, oxidative stress, and iron me tabolism emerging as central factors. Additionally, various signaling pathways, molecules, and organelles also contribute to the regulation and progression of ferroptosis. Activation of ferroptosis has significant implications for sepsis-related inflammation, providing both a valuable area for scientific investigation and a potential target for therapeutic interventions. This article reviews the biological processes and molecular mechanisms of ferroptosis, as well as the small molecules and signaling pathways that regulate it. Additionally, we discuss the role of ferropto sis in the progression of sepsis and its contribution to organ damage.
ISSN: 2957-5443
Volume 3, Issue 3
September 2025
Pages: 71-115
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