Research progress on ferroptosis in the pathogenesis of sepsis-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress on ferroptosis in the pathogenesis of sepsis

Yu Xiang, Jiameng Liu, Huan Li, Kecheng Zhai, Xingchen Yue, Shangping Fang

Anesthesia Laboratory and Training Center, School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui Province, China.

Address correspondence to: Shangping Fang, Anesthesia Laboratory and Training Center, School of Anesthesiology, Wannan Medical College, No.22, Wenchang West Road, Lugang Street, Yijiang Dis trict, Wuhu 241002, Anhui Province, China. Tel: +86-19855362767; E-mail: 20180041@wnmc.edc. cn.

Acknowledgement: This work was supported by Anhui Province College Student Innovation and Entrepreneurship Project (S202310368027 and S202410368031).

DOI: https://doi.org/10.61189/843291jljiwm

Received December 12, 2024; Accepted February 14, 2025; Published September 30, 2025

Highlights

●Lipid metabolism and iron metabolism pathways are key biological pathways involved in ferroptosis.

● Ferroptosis exhibits complex crosstalk with other cell death forms in sepsis, with significant implications for dis ease pathogenesis and therapy.

● Ferroptosis plays a critical role in sepsis-related organ damage and prognosis.

● This review suggests directions and perspectives for treating ferroptosis and sepsis in the perioperative period.

Abstract

Ferroptosis is a newly identified form of cell death that has garnered attention in recent years. Current research has clarified several key mechanisms of ferroptosis, with reactive oxygen species, oxidative stress, and iron me tabolism emerging as central factors. Additionally, various signaling pathways, molecules, and organelles also contribute to the regulation and progression of ferroptosis. Activation of ferroptosis has significant implications for sepsis-related inflammation, providing both a valuable area for scientific investigation and a potential target for therapeutic interventions. This article reviews the biological processes and molecular mechanisms of ferroptosis, as well as the small molecules and signaling pathways that regulate it. Additionally, we discuss the role of ferropto sis in the progression of sepsis and its contribution to organ damage.

Keywords: Ferroptosis, sepsis, inflammation, GPX4

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