Impact of intestinal immunologic barrier dysfunction on perioperative complications
Wenxin Shi, Yajun Hu, Jin Lan, Jun Xiong, Zhiyong Li
Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.
Address correspondence to: Jun Xiong, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: xiongjun2001@163.com; Zhiyong Li, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: zhiyongli@smmu.edu.cn.
Acknowledgement: This work was supported by grants from the Shanghai Science (23ZR1477400) and Technology Commission Project (201409004600).
DOI: https://doi.org/10.61189/629158xrbqam
Received October 28, 2024; Accepted January 7, 2025; Published June 30, 2025
Highlights
● Intestinal barrier dysfunction increases the risk of perioperative complications.
● The immunologic barrier is crucial for maintaining intestinal homeostasis.
● Perioperative factors compromise the intestinal immunologic barrier, increasing infection risk.
● An imbalance between intestinal microbiota and immune cells affects postoperative recovery.
● Clinical intervention studies targeting the intestinal barrier are summarized.
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