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Progress in heatstroke-induced multiple organ damage

Ruilong Li1,2*, Dezhi Guo1,2*, Tianying Li1,2, Panpan Hu1,3, Tianying Xu1


1Department of Anesthetic Pharmacology, School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China. 2College of Basic Medicine, Second Military Medical University/Naval Medical University, Shanghai 200433, China. 3National Key Laboratory of Immunity & Inflammation, Second Military Medical University/Naval Medical University, Shanghai 200433, China. 

* The authors contribute equally.


Address correspondence to: Tianying Xu, Department of Anesthetic Pharmacology, School of Anesthesiology, Second Military Medical University/Naval Medical University, 800 Xiangyin Road, Shanghai 200433, China. Tel: +86 021 81872029, E-mail: xutianying@smmu.edu.cn; Panpan Hu, Department of Anesthetic Pharmacology, School of Anesthesiology, National Key Laboratory of Immunity & Inflammation, Second Military Medical University/Naval Medical University, 800 Xiangyin Road, Shanghai  200433, China. Tel: +86 021 81872029, E-mail: hpp510@smmu.edu.cn.


Acknowledgement: This work was supported by the Basic Medical Research Fund of Naval Medical University (2023QN034). The authors would like to thank all the guest editors and anonymous reviewers for their constructive comments.


DOI: https://doi.org/10.61189/313377zqjuff


Received January 23, 2024; Accepted April 29, 2024; Published September 30, 2024


Highlights

● Patients with heatstroke often suffer from multiple organ dysfunction and have a high fatality rate. 

● The molecular mechanisms underlying multiple organ damage in heatstroke are complex. 

● This review outlines the manifestations of multiple organ dysfunction caused by heatstroke and explores the possible molecular mechanisms involved.

Abstract

Heatstroke is a life-threatening acute condition characterized by dysregulated temperature control, resulting in high core temperature and multi-organ dysfunction. Despite extensive research, the molecular mechanisms underlying heatstroke-induced organ damage have not been fully elucidated. This review aims to summarize recent advancements in the field of heatstroke, focusing on etiological factors, organ damage, and molecular mechanisms. By exploring the intricate interplay between heat-related cytotoxicity, inflammatory response, and tissue dysfunction, this review offers insights for future research and clinical practice in managing heatstroke patients. Further investigations are warranted to elucidate the specific mechanisms of organ damage and improve treatment strategies for heatstroke.

Keywords: Heatstroke, organ damage, molecular mechanisms

Ruilong Li, Dezhi Guo, Tianying Li, et al. Progress in heatstroke-induced multiple organ damage. Perioper Precis Med. 2024 Sep; 2(3):73-89. doi: 10.61189/313377zqjuff
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