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Limb nerve block localization using deep learning-driven segmentation: A review

Jiaxun Jiang1, Miao Zhou2, Liangqing Lin3, Haipo Cui1, Long Liu1, Jiaen Wu1, Zhaopeng Zhou1


1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. 2Jiangsu Cancer Hospital, Nanjing 213164, Jiangsu Province, China. 3Anesthesiology, The First Hospital of Putian, Putian 351100, Fujian Province, China.


Address correspondence to: Haipo Cui, School of Health Science and Engineering, University of Shanghai for Science and Technology, No. 516 Jungong Road, Yangpu District, Shanghai 200093, China. E-mail: h_b_cui@163.com.


DOI: https://doi.org/10.61189/295165xbmhth


Received April 1, 2025; Accepted May 12, 2025; Published December 31, 2025


Highlights

● Deep learning-powered nerve block segmentation significantly contributes to optimized perioperative pain management by enhancing the precision and safety of regional anesthesia. 

● Advanced architectures, particularly U-Net variants, dominate peripheral nerve block segmentation, offering high precision and adaptability to medical imaging challenges. 

● Deep learning enhances clinical workflows by improving segmentation accuracy and efficiency in upper and lower limb nerve blocks, thereby supporting procedural success. 

● Future efforts will focus on improving model robustness and generalizability to address limitations such as data variability and limited adaptability, facilitating broader clinical adoption.

Abstract

Effective pain management is a cornerstone of optimal perioperative care, significantly impacting patient recovery and outcomes. Regional anesthesia, particularly peripheral nerve blocks, plays a crucial role in achieving this by providing targeted analgesia. While ultrasound guidance has enhanced the precision of these procedures, challenges persist in accurately identifying nerve structures due to inherent image quality issues. Addressing these challenges is critical for improving the efficacy and safety of nerve blocks. Recent years have witnessed significant advances in medical image processing powered by deep learning, particularly in the segmentation of peripheral nerve blocks. This review summarizes current research progress and emerging techniques in this domain. We first introduce commonly used segmentation models, including Fully Convolutional Networks, U-Net and its variants,  and task-specific network architectures. We then examine the application of deep learning to the segmentation of upper and lower limb nerve blocks, highlighting improvements in accuracy and efficiency. Current limitations-such as challenges with data heterogeneity and model generalization-are critically analyzed, and future directions are proposed to enhance model robustness and clinical scalability. Ultimately, this paper underscores the potential of deep learning to revolutionize peripheral nerve block localization through automated and reliable image segmentation.

Keywords: Deep learning, medical image processing, nerve block, perioperative medical applications

Cite

Jiang JX, Zhou M, Lin LQ, Cui HP, Liu L, Wu JE, Zhou ZP. Limb nerve block localization using deep learning-driven segmentation: A review. Perioper Precis Med. 2025 Dec; 3 (4): 134-151. doi: 10.61189/295165xbmhth

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