Research progress of sphingosine 1-phosphate receptor 3 in the cardiovascular system

Sphingosine 1-phosphate receptor 3 (S1PR3) is one of the five receptors of sphingosine 1-phosphate, actively participating in physiological processes such as angiogenesis and endothelial cell differentiation. Widely expressed in various tissue cells such as muscle cells, immune cells, lymphocytes, endothelial cells, and fibroblasts, S1PR3 has garnered increasing attention in research, showcasing its involvement in various pathophysiological processes and its important role in the body’s inflammatory and immune responses. In the cardiovascular system, S1PR3 is involved in many pathophysiological processes, including angiogenesis, maintaining vascular permeability, lymphocyte transport, and physiological function of the heart. Moreover, it also plays a regulatory role in the treatment of cardiovascular diseases, such as heart ischemia/reperfusion, atherosclerosis, and cardiac fibrosis. S1PR3 also plays a crucial role in evaluation and treatment during the cardiovascular system in perioperative period and has a powerful therapeutic effect in sepsis. Regulators related to S1PR3 exhibit therapeutic potential in clinical treatments of cardiovascular diseases. This article aims to explore the role and research progress of S1PR3 in the cardiovascular system.