Research progress of oxidative stress in sepsis-associated liver injury-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress of oxidative stress in sepsis-associated liver injury

Hui Su^1,2, Tianying Xu³, Renke Sun^1,2, Yu Xiang^1,2, Yangmengna Gao^1,2, Kecheng Zai^1,2, Shangping Fang^1,2

¹School of Anesthesiology, ²Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, China. ³School of Anesthesiology, Department of Anesthetic Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.

Address correspondence to: Shangping Fang, Anesthesia Laboratory and Training Center, School of Anesthesiology, Wannan Medical College, No. 22, Wenchang West Road, Lugang Street, Yijiang District, Wuhu 241002, Anhui, China. Tel: 19855362767; E-mail: 20180041@wnmc.edc.cn.

Acknowledgements: This work was supported by Key Project Research Fund of Wannan Medical College (WK2022Z10) and Research Grant for College Students of Wannan Medical College (WK2022XS26).

DOI: https://doi.org/10.61189/270899wnwlnz

Received September 17, 2023; Accepted November 28, 2023; Published March 31, 2024

Highlights

● The approaches of antioxidant therapy to alleviate sepsis-associated liver injury are summarized from the per spective of oxidative stress in different cells of the liver.

● Reactive oxygen species, one of the main substances that induce oxidative stress, affects the molecular mecha nism of the relevant signaling pathways.

● Antioxidant therapy is helpful for the recovery of various liver cells in sepsis-associated liver injury and is expect- ed to advance basic and clinical research.

Abstract

Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment and poor prognosis pose significant challenges to healthcare in recent years. One of the main pathogeneses of sepsis-induced liver injury is oxidative stress (OS), which refers to a state where the antioxidant system cannot balance oxidative products, leading to the accumulation of excessive oxidative products in the body. When sepsis occurs, the amount of reactive oxygen species produced by the body increases far beyond the levels that can be scavenged by the antioxidant system, thus damaging liver cells and aggravating liver damage. This article introduces the oxidative/antioxidant system, oxidative stress-related pathways, and the molecular mechanism of OS in various types of hepatocytes, with emphasis on the antioxidant treatment on different hepatocytes, in order to understand the mechanism of OS involved in the development and progression of sepsis-associated liver injury. As the research deepens, improving liver function through the treatment of different cells and facilitating related clinical research are expected to provide a new target pathway for the treatment of sepsis-associated liver injury.

Keywords: Sepsis-associated liver injury, liver injury, oxidative stress, reactive oxygen species