Volume 4, Issue 3

Research Article
Open Access
Development and evaluation of a portable, wireless endoscopic shaving system for minimally invasive orthopedic surgery
Chao Qi
Chao Qi
Suzhou Dajiang Medical Technology Co., Ltd., Suzhou 215011, Jiangsu, China.
,
Kunyu Chen
Kunyu Chen
230259214@seu.edu.cn
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, Jiangsu, China.
,
Jianfei Sun
Jianfei Sun
sunzaghi@seu.edu.cn
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, Jiangsu, China.
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Objective: Due to the shortcomings of large size, operational complexity, infection risks, and high costs, traditional endoscopic shaving systems are limited in complex surgical procedures and primary healthcare settings. To address these limitations, this study proposes the design of a portable endoscopic surgical shaving system as an alternative to traditional systems. Methods: Wireless operation was achieved by integrating the control, power supply, and sensing modules into a detachable handle unit, thereby eliminating dependence on external host devices and cables while reducing the cost of fabrication. Additionally, the system performance was systematically evaluated and compared with thereby eliminating clinical products. Results: Experimental results suggest that the system meets clinical requirements in terms of power output, mechanical characteristics, noise emission, and cutting efficiency of the shaving head. While achieving the functional equivalence to conventional systems, it effectively addresses their inherent limitations. In addition, the cleaning efficiency is significantly improved by the modular detachable design, thereby reducing infection risk. The wireless connection function realized by Bluetooth technology can be linked with the tablet device for real-time speed adjustment and performance monitoring, which greatly improves the intelligence level of the system. Conclusion: The portable endoscope shaving system proposed in this paper, through portable engineering design, achieves structural innovation, cost reduction, and infection risk control. Its properties are comparable to the clinical products, which meet the needs of minimally invasive orthopedic surgery, and show a good clinical application prospect.

Review Article
Open Access
Fluorescence-enhanced isothermal amplification for multiplex pathogen detection: Emerging strategies and persistent challenges
Yuanshou Zhu
Yuanshou Zhu
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Xitian Xu
Xitian Xu
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Yuxin Chen
Yuxin Chen
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Mengyuan Huang
Mengyuan Huang
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Shoulong Wang
Shoulong Wang
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Haoyu Li
Haoyu Li
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Zhigang Zhu
Zhigang Zhu
zgzhu@usst.edu.cn
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
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Multiplex pathogen detection is essential for addressing the increasing complexity of infectious diseases and co-infections, yet conventional polymerase chain reaction-based methods remain hindered by the requirement for sophisticated laboratory infrastructure. Isothermal amplification offers a robust alternative for point-of-care testing, though high-order multiplexing in these systems has historically been limited by signal discrimination challenges. In this review, we synthesize recent breakthroughs in fluorescence-enhanced isothermal amplification, which have transformed multiplex diagnostics through advanced signal encoding and intelligent processing. We illustrate how the convergence of diverse molecular engines, ranging from sequence-specific probes to orthogonal clustered regularly interspaced short palindromic repeats-associated effectors and programmable DNA logic circuits, enables precise, multi-target identification in a single reaction. Beyond the biochemical framework, we further discuss the integration of these molecular strategies with microfluidic platforms, portable optical detection systems, and deep learning-based signal analysis, which collectively facilitate the transition from laboratory prototypes to automated diagnostic platforms. Finally, we examine persistent challenges, including assay crosstalk and amplification bias, and outline future directions toward accessible and scalable multiplex diagnostic systems.
Review Article
Open Access
Immunotherapy and related nanodevices for Helicobacter pylori
Haowei Wu
Haowei Wu
College of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Clinical Research Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
,
Jing Wang
Jing Wang
Clinical Research Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China; College of Life Sciences, Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang, China.
,
Tinglin Zhang
Tinglin Zhang
Clinical Research Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Marine Medicine and Medicine Transformation, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
,
Jie Gao
Jie Gao
gaojiehighclea@smmu.edu.cn.
College of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Clinical Research Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Marine Medicine and Medicine Transformation, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China; College of Life Sciences, Mudanjiang Medical University, Mudanjiang 157000, Heilongjiang, China.
,
Haipo Cui
Haipo Cui
h_b_cui@163.com.
College of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
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Helicobacter pylori (HP) infection poses a major global health challenge. As antibiotic resistance continues to rise, the efficacy of conventional antibiotic therapies has become increasingly limited. Immunotherapy has gained substantial research interest due to its potential to overcome resistance and elicit durable immune responses. This article systematically reviews current immunotherapeutic strategies for HP, with an emphasis on recent advances in vaccine and antibody-based therapies, and particularly highlights the application of nanodevice-based immunotherapy. Furthermore, it analyzes the major challenges hindering the development and clinical translation of HP immunotherapy and outlines future research directions, aiming to inform the design of more effective strategies for the prevention and control of HP infection.
Review Article
Open Access
Transformer-based methods for remote photoplethysmography in non-contact physiological measurement: A systemic review
Miaomiao Peng
Miaomiao Peng
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Rongguo Yan
Rongguo Yan
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
,
Xudong Guo
Xudong Guo
guoxd@usst.edu.cn
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200093, China.
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Traditional contact-based physiological monitoring techniques are limited by their comfort and convenience, making them unsuitable for continuous and unobtrusive monitoring in medical environments and daily healthcare applications. Remote photoplethysmography (rPPG) is a non-contact physiological sensing technique that estimates vital physiological signals, such as heart rate and respiration rate, from subtle skin color variations captured in facial videos. However, the practical application of rPPG remains challenging because the physiological signals extracted from facial regions of interest are weak and can be easily overwhelmed by non-stationary noise, such as changes in ambient illumination and subject head motion, resulting in a low signal-to-noise ratio. Recently, Transformer architectures have demonstrated strong capabilities in global dependency modeling through self-attention mechanism, enabling effective extraction of long-range temporal physiological features while suppressing global interference. These advantages provide a new paradigm to overcome the performance bottlenecks of conventional rPPG methods. This review provides a comprehensive overview of recent progress on Transformer-based rPPG research. Specifically, it covers multiple research directions, including pure transformer end-to-end model, CNN-Transformer hybrid model, multi-stream information fusion frameworks, lightweight models for edge deployment, self-supervised learning frameworks, and extended applications in physiological monitoring. Additionally, this review discusses current limitations and challenges of Transformer-based rPPG systems and highlights future research opportunities for developing new non-contact physiological monitoring technologies.
Progress in Medical Devices
ISSN: 2957-5478
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