This systematic review synthesizes current epidemiological evidence on the impacts of climate change on vector-borne disease transmission patterns. Following PRISMA guidelines, we analyzed 127 studies examining relationships between climatic variables and disease incidence of malaria, dengue, Lyme disease, and other vector-borne illnesses. Results demonstrate significant associations between temperature increases, precipitation changes, and altered transmission dynamics across diverse geographic regions. The evidence supports the development of climate-informed surveillance and early warning systems for vector-borne disease control.