Microneedle (MN) vaccines offer a promising alternative to conventional intramuscular (IM) injections, potentially enhancing immunogenicity by targeting the skin's rich immune network. This study aims to synthesize existing evidence comparing the immunogenicity of MN vaccines versus IM injections.

Evidence from this meta-analysis strongly supports the immunological non-inferiority of MN vaccines compared to conventional IM delivery. The trend towards enhanced cellular immunity and improved safety profile underscores the potential of MN technology as a viable and effective alternative for vaccination, aligning with global health goals to improve vaccine access and acceptability.