Background: Achieving optimal vaccination coverage remains challenging in low-resource settings due to logistical constraints. This study aimed to model the potential impact of microneedle patch (MNP) vaccination on immunization coverage rates in resource-limited settings.The MNP strategy with current infrastructure increased mean vaccination coverage from 68.3% (CIS) to 76.8% (95% UI: 74.2-79.1%), while the optimized MNP strategy achieved 84.5% coverage (95% UI: 81.9-86.8%). The optimized MNP strategy averted an additional 12.7 DALYs (95% UI: 10.3-15.1) per 1000 population annually compared to CIS. Key drivers of coverage improvement were reduced cold-chain dependency (accounting for 42% of coverage gain) and simplified administration procedure (35% of coverage gain). Sensitivity analysis showed the model was most sensitive to MNP cost and community health worker training effectiveness.