Ruilong Li^1,2*, Dezhi Guo^1,2*, Tianying Li^1,2, Panpan Hu^1,3, Tianying Xu¹

¹Department of Anesthetic Pharmacology, School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China. ²College of Basic Medicine, Second Military Medical University/Naval Medical University, Shanghai 200433, China. ³National Key Laboratory of Immunity & Inflammation, Second Military Medical University/Naval Medical University, Shanghai 200433, China. 

* The authors contribute equally.

Address correspondence to: Tianying Xu, Department of Anesthetic Pharmacology, School of Anesthesiology, Second Military Medical University/Naval Medical University, 800 Xiangyin Road, Shanghai 200433, China. Tel: +86 021 81872029, E-mail: xutianying@smmu.edu.cn; Panpan Hu, Department of Anesthetic Pharmacology, School of Anesthesiology, National Key Laboratory of Immunity & Inflammation, Second Military Medical University/Naval Medical University, 800 Xiangyin Road, Shanghai  200433, China. Tel: +86 021 81872029, E-mail: hpp510@smmu.edu.cn.

Acknowledgement: This work was supported by the Basic Medical Research Fund of Naval Medical University (2023QN034). The authors would like to thank all the guest editors and anonymous reviewers for their constructive comments.

DOI: https://doi.org/10.61189/313377zqjuff

Received January 23, 2024; Accepted April 29, 2024; Published September 30, 2024

Highlights

● Patients with heatstroke often suffer from multiple organ dysfunction and have a high fatality rate. 

● The molecular mechanisms underlying multiple organ damage in heatstroke are complex. 

● This review outlines the manifestations of multiple organ dysfunction caused by heatstroke and explores the possible molecular mechanisms involved.