Research progress of sphingosine 1-phosphate receptor 3 in the cardiovascular system-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress of sphingosine 1-phosphate receptor 3 in the cardiovascular system

Yangmengna Gao^1,2, Ran Yuan^1,2, Kecheng Zhai^1,2, Hui Su^1,2, Renke Sun^1,2, Shangping Fang^1,2

¹School of Anesthesiology, ²Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China.

Address correspondence to: Shangping Fang, Anaesthesiology Experimental Training Center, College of Anesthesiology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel:+86-19855362767. E-mail: 20180041@wnmc.edu.cn.

Acknowledgement: Key Project Research Fund of Wannan Medical College (WK2022Z10); National College Student Innovation and Entrepreneurship Project (202310368016); Anhui Province College Student Innovation and Entrepreneurship Project (S202210368107, S202210368108); Student Research Funding Project of Wannan Medical College (WK2023XS10).

DOI: https://doi.org/10.61189/076009mwdtns

Received January 25, 2024; Accepted March 19, 2024; Published Jane 30, 2024

Highlights

● Sphingosine 1-phosphate receptor 3 (S1PR3) promotes the proliferation of vascular endothelial cells and enhances barrier function.

● S1PR3 is a promising target for clinical treatment of cardiac ischemia-reperfusion, cardiac fibrosis and atherosclerosis.

● Fingolimod and other modulators of S1PR3 have shown therapeutic efficacy in phase I and II clinical trials for cardiovascular diseases.

● S1PR3 play crucial roles in the perioperative evaluation and treatment of the cardiovascular system, as well as in sepsis.

Abstract

Sphingosine 1-phosphate receptor 3 (S1PR3) is one of the five receptors of sphingosine 1-phosphate, actively participating in physiological processes such as angiogenesis and endothelial cell differentiation. Widely expressed in various tissue cells such as muscle cells, immune cells, lymphocytes, endothelial cells, and fibroblasts, S1PR3 has garnered increasing attention in research, showcasing its involvement in various pathophysiological processes and its important role in the body’s inflammatory and immune responses. In the cardiovascular system, S1PR3 is involved in many pathophysiological processes, including angiogenesis, maintaining vascular permeability, lymphocyte transport, and physiological function of the heart. Moreover, it also plays a regulatory role in the treatment of cardiovascular diseases, such as heart ischemia/reperfusion, atherosclerosis, and cardiac fibrosis. S1PR3 also plays a crucial role in evaluation and treatment during the cardiovascular system in perioperative period and has a powerful therapeutic effect in sepsis. Regulators related to S1PR3 exhibit therapeutic potential in clinical treatments of cardiovascular diseases. This article aims to explore the role and research progress of S1PR3 in the cardiovascular system.

Keywords: Sphingosine 1-phosphate, sphingosine 1-phosphate receptor 3, cardiovascular system

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