Research progress on the mechanisms of traditional Chinese medicine extracts in improving acute lung injury in sepsis-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress on the mechanisms of traditional Chinese medicine extracts in improving acute lung injury in sepsis

Sixu Chen^1,2,5,*, Jiayin Wang^3,5,*, Weiqi Lin^4,5,*, Xinyi Xie^3,5, Yutong Sun^4,5, Haiyi Qian^3,5, Yichen He^1,2,5, Cuifeng Zhang^1,2,5

¹School of Anesthesiology, Wannan Medical College, Wuhu, Anhui Province, China. ²Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu, Anhui Province, China. ³School of Pharmacology, Wannan Medi-cal College, Wuhu, Anhui Province, China. ⁴School of Clinical Medicine, Wannan Medical College, Wuhu, Anhui Province, China. ⁵Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu, Anhui Province, China.

* The authors contribute equally and co-first authors.

Address correspondence to: Cuifeng Zhang, School of Anesthesiology, Wannan Medical College, Wuhu, Anhui Province, China, No. 22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui Province, China. Tel: +86-15551257181. E-mail: zhangcuifeng@wnmc.edu.cn.

DOI: https://doi.org/10.61189/579841iexakc

Received March 5, 2025; Accepted May 12, 2025; Published December 31, 2025

Highlights

● The pathogenesis of sepsis-induced acute lung injury is outlined.

● A comprehensive overview of the role of TCM extracts in sepsis-induced acute lung injury is provided.

● The clinical application of classical TCM extracts is summarized in detail.

Abstract

Acute lung injury (ALI) is a severe and life-threatening condition. Traditional Chinese medicine (TCM) extracts, which are rich in bioactive compounds with demonstrated efficacy against ALI, have exhibited considerable therapeutic potential. This review provides a comprehensive analysis of the therapeutic effects of TCM extracts in mitigating sepsis-induced ALI, synthesizing current evidence on their clinical advantages and the underlying molecular and cellular mechanisms. Furthermore, it outlines the major challenges and unresolved issues in the field, offering insights that may guide future research and enhance the application of TCM in managing sepsis-associated respiratory complications.

Keywords: Traditional Chinese medicine extracts, sepsis, acute lung injury, mechanisms, research progress

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