Research progress on the pharmacological activity and mechanism of chlorogenic acid in alleviating acute kidney injury in sepsis patients-ZENTIME PUBLISHING CORPORATION LIMITED

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Research progress on the pharmacological activity and mechanism of chlorogenic acid in alleviating acute kidney injury in sepsis patients

Renke Sun^1,2, Hui Su^1,2, Kecheng Zhai^1,2, Yangmengna Gao^1,2, Shangping Fang^1,2

¹School of Anesthesiology, ²Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, China.

Address correspondence to: Shangping Fang, Anaesthesiology Experimental Training Center, College of Anesthesiology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel:+86-19855362767; E-mail: 20180041@wnmc.edc.cn.

Acknowledgements: This work was supported by Wannan Medical College emphasis scientific research fund (WK2022Z10) and Anhui University Students’ innovation and entrepreneurship fund (S202210368107).

DOI: https://doi.org/10.61189/955623wnfjqd

Received September 28, 2023; Accepted November 14, 2023; Published December 31, 2023

Highlights

● The pharmacological action of chlorogenic acid was summarized.

● The mechanism of acute kidney injury (AKI) was investigated.

● The signaling pathways through which chlorogenic acid plays its role in AKI were summarized for the first time.

● A possible new drug for treating a common perioperative complication, namely sepsis-induced AKI, is revealed.

Abstract

Sepsis-induced acute kidney injury (SAKI) is a serious perioperative complication and a common clinical syndrome characterized by a rapid deterioration in renal function with a high incidence of 70%. The causes of SAKI include impaired mitochondrial function of renal tubular epithelial cells, oxidative stress, inflammatory reaction and renal microcirculation disorder. Chlorogenic acid, as a natural product of plant origin, has various biological activities, such as antibacterial, antiviral, and anti-tumor, and plays a significant role in the treatment of SAKI. This article reviews the pharmacological activities of chlorogenic acid and the signaling pathways involved in relieving SAKI, in order to provide a theoretical basis for in-depth study of the mechanisms underlying the alleviation of SAKI and the confirmation of potential therapeutic targets.

Keywords: Chlorogenic acid, sepsis-induced acute kidney injury, pharmacological activity, mechanism, signaling pathway

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