Keywords: Chlorogenic acid, sepsis-induced acute kidney injury, pharmacological activity, mechanism, signaling pathway
Research progress on the pharmacological activity and mechanism of chlorogenic acid in alleviating acute kidney injury in sepsis patients
Renke Sun1,2, Hui Su1,2, Kecheng Zhai1,2, Yangmengna Gao1,2, Shangping Fang1,2
1School of Anesthesiology, 2Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, China.
Address correspondence to: Shangping Fang, Anaesthesiology Experimental Training Center, College of Anesthesiology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel:+86-19855362767; E-mail: 20180041@wnmc.edc.cn.
Acknowledgements: This work was supported by Wannan Medical College emphasis scientific research fund (WK2022Z10) and Anhui University Students’ innovation and entrepreneurship fund (S202210368107).
DOI: https://doi.org/10.61189/955623wnfjqd
Received September 28, 2023; Accepted November 14, 2023; Published December 31, 2023
Highlights
● The pharmacological action of chlorogenic acid was summarized.
● The mechanism of acute kidney injury (AKI) was investigated.
● The signaling pathways through which chlorogenic acid plays its role in AKI were summarized for the first time.
● A possible new drug for treating a common perioperative complication, namely sepsis-induced AKI, is revealed.
Abstract
Keywords: Chlorogenic acid, sepsis-induced acute kidney injury, pharmacological activity, mechanism, signaling pathway