Home | Help Center

Endless possibilities in academia

Thyroid disease-related sleep disorders and its diagnostic and therapeutic recommendations: A literature review

Qin Yin1,*, Jinfeng Wang2,*, Shu Wang3, Yu'e Sun4, Wei Cheng1,5, Yinming Zeng1


1Department of Pain Clinic, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China. 2Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221000, China. 3Department of Anesthesiology, Yancheng Third People's Hospital, Yancheng 224000, China. 4Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, China. 5Department of Anesthesiology, Huai'an First People's Hospital Affiliated to Nanjing Medical University, Huai'an 223000, China.

*The authors contribute equally.


Address correspondence to: Yinming Zeng, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No.99 West Huaihai Road, Xuzhou 221000, China. E-mail: xzkj2297@163.com. Wei Cheng, Department of Anesthesiology, Huai’an First People’s Hospital Affiliated to Nanjing Medical University, No.1 West Yellow River Road, Huai’an 223000, China/Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No.99 West Huaihai Road, Xuzhou 221000, China. E-mail: hayyyzxx@163.com. 


DOI: https://doi.org/10.61189/657934sjvovo


Received August 12, 2023; Accepted November 28, 2023; Published December 31, 2023


Highlights

● Complains of sleepless and tinnitus are common in sleep clinics, which is a different type of sleep disorder. In this article, we first summarize this disorder, which is defined as thyroid disease-related sleep disorder (TSD), and propose to categorize it as insomnia secondary to a somatic disorder.

● We have attempted to provide some preliminary diagnostic and therapeutic recommendations for TSD.

● In the treatment of TSD, we suggest relying on the theory of integrating Chinese and Western medicine, emphasizing holistic diagnosis and treatment, and precise medication.

Abstract

As perioperative medicine evolves, more hospitals are offering comfort sleep clinics. Thyroid disorders (e.g., hypothyroidism, hyperthyroidism, and thyroid cancer) affect the peripheral circadian clock. Elevated serum thyroid-stimulating hormone levels have been found to associate with the incidence of thyroid cancer in humans, but the relationship between circadian disruption and thyroid disease requires further investigation. Malignant transformation of thyroid nodules is characterized by disruption of the expression of biological clock genes. Sleep clinics often see patients complaining of sleepiness and tinnitus. These patients often have comorbid thyroid disorders and are therefore highly susceptible to misdiagnosis or underdiagnosis. In this article, we first summarize this category of disorders, which we propose to classify as insomnia secondary to somatic disease and define as thyroid disease-related sleep disorder (TSD). The primary and common clinical complaints of TSD patients are different types of sleep disorders. In addition, we attempt to provide some preliminary diagnostic and therapeutic recommendations for TSD in the hope that it may assist healthcare professionals in the early diagnosis and management of this disorder.

Keywords: Thyroid disease, sleep disorders, definition, diagnose and treatment, traditional Chinese medicine

Yin Q, Wang JF, Wang S, et al. Thyroid disease-related sleep disorders and its diagnostic and therapeutic recommendations: A literature review. Perioper Precis Med. 2023 Dec;1(3):101-118. doi: 10.61189/657934sjvovo. 

Copy