Lindong Cheng¹, Ping Li², Duy Khanh La^3,4, Zhen Xing^5,#, Chunhua Liao^6,# 

¹Graduate School, Hebei North University, Hebei 075000, China. ²Graduate School, Wannan Medical College, Anhui 241000, China. ³Foreign Training Group, Naval Military Medical University, Shanghai 200433, China. ⁴Faculty of Medicine, Vietnam Military Medical University, Hanoi 100000, Vietnam. ⁵Department of Anesthesiology, the First Affiliated Hospital of Hebei North University, Hebei 075000, China. ⁶School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China. 

 ^#Address correspondence to: Chunhua Liao, School of Anesthesiology, Second Military Medical University/Naval Medical University, Shanghai 200433, China. E-mail: liaochh7@smmu.edu.cn; Zhen Xing, Department of Anesthesiology, the First Affiliated Hospital of Hebei North University, Hebei 075000, China. E-mail: xingzhen@sina.com.

Received March 19, 2023; Accepted May 16, 2023; Published June 30, 2023

DOI: https://doi.org/10.61189/863627autews

Highlights

● Candidiasis is a substantial cause of perioperative mortality in immunocompromised and immunodeficient patients. 

● β-glucan and α-mannan are two major pathogen-associated molecular patterns in the Candida albicans cell walls recognized by C-type lectin receptors (CLRs). 

● CLRs, such as Dectin-1 and Dectin-2, as β-glucan and α-mannan receptors, are essentially involved in recogni tion of Candida albicans. 

● CLRs are promising drug targets for treating chronic candidiasis.