Endoscopic submucosal dissection (ESD) is now considered the standard endoscopic resection technique for patients with early gastric cancer. ESD provides a higher rate of complete resection and a lower local recurrence rate. However, ESD results in larger and deeper ulcers, and post-ESD bleeding is a common complication. Bleeding after ESD cannot be completely avoided, especially in patients with large-sized gastric ulcers, those on anticoagulant therapy, and elderly patients. Most bleeding can be controlled by endoscopic hemostatic methods during the procedure, such as the application of hemostatic clips for ulcer closure and hemostatic powder for ulcer shielding. In addition, we also found the potential value of using new materials such as self-assembling peptides for hemostasis. This review first revisits the definition of endoscopic resection of the digestive tract. Then, we discuss post-ESD bleeding and the influence of risk factors such as the location, size, and depth of the surgical lesion, anticoagulant medication use, and the patient's age and lifestyle. Finally, we review the treatment methods for post-ESD bleeding, including intraoperative ulcer closure, ulcer shielding, and the application of thrombin and adrenaline injection.