Volume 1, Issue 2

Open Access
A Clinical Study on the Application of Hyperbaric Oxygen Therapy in Hand Surgery Trauma
Jianhua Xia
Jianhua Xia
Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai, China
,
Xiangcheng Zhang
Xiangcheng Zhang
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
,
Yonggang Peng
Yonggang Peng
pengy@ufl.edu
The University of Florida, Gainesville, USA
2026 Jun;1(2):45-50

Background: Traumatic injuries to the hand, including crush injuries, avulsions, devascularizations, and complex fractures with soft tissue compromise, present significant surgical challenges due to compromised tissue perfusion, edema, and high risk of infection and necrosis. Hyperbaric Oxygen Therapy (HBOT), which involves breathing 100% oxygen at pressures greater than one atmosphere absolute (ATA), is an adjunctive treatment proposed to enhance wound healing in such complex scenarios by maximizing tissue oxygenation. Objective: This study aimed to evaluate the clinical efficacy and outcomes of adjunctive HBOT in the management of acute traumatic hand injuries requiring surgical intervention. Methods: A prospective, randomized controlled trial was conducted involving 80 patients with severe traumatic hand injuries (Gustilo Anderson type IIIB/C open fractures, severe crush injuries with devitalized tissue, or replantation/revascularization cases). Patients were randomly assigned to the Standard Care Group (n=40), receiving surgical management (debridement, fixation, vascular repair, flap coverage as needed) and conventional post operative care, or the HBOT Group (n=40), receiving standard surgical care plus an adjunctive HBOT protocol (2.4 ATA for 90 minutes, twice daily for 5 days, then once daily for a total of 20 30 sessions). Primary outcomes included wound healing rate, time to complete wound closure/graft take, flap survival rate, and infection rate. Secondary outcomes encompassed functional recovery (Total Active Motion   TAM, grip strength), analgesic requirement, and length of hospital stay. Results: The HBOT group demonstrated statistically superior outcomes. The incidence of major post operative complications (flap/graft failure, deep infection, osteomyelitis) was significantly lower (15% vs. 37.5% in the control group, p<0.05). Time to complete wound closure or successful graft/flap take was reduced by an average of 4.2 days (p<0.01). Flap survival rates were 94% in the HBOT group compared to 82% in controls (p<0.05). Functionally, the HBOT group showed significantly greater TAM recovery at 3 month follow up (p<0.01) and required fewer opioid analgesics in the first post operative week (p<0.05). Conclusion: Adjunctive HBOT significantly improves wound healing, reduces complication rates, and enhances functional recovery in patients with severe traumatic hand injuries. It serves as a valuable adjuvant to meticulous surgical technique by modulating the ischemic reperfusion injury, controlling edema, and augmenting neovascularization, thereby optimizing conditions for tissue survival and repair.

Open Access
Variations in Pre injury Anticoagulant Use Among Traumatic Brain Injury Patients Across Different Trauma Center Levels
Jianhua Xia
Jianhua Xia
Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai, China
,
Yonggang Peng
Yonggang Peng
The University of Florida, Gainesville, USA
,
Wei Zhang
Wei Zhang
orthozhang@163.com
The Sixth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China
2026 Jun;1(2):51-55
Background: Pre injury use of anticoagulant and antiplatelet medications is a significant risk factor for worse outcomes in patients with traumatic brain injury (TBI). These medications are commonly prescribed for conditions such as atrial fibrillation and venous thromboembolism. However, the prevalence and patterns of their use among TBI patients presenting to different levels of trauma centers remain inadequately characterized. Understanding these variations is crucial for risk stratification, protocol development, and resource allocation. Objective: This study aimed to determine the prevalence of pre injury anticoagulant (AC) and antiplatelet (AP) medication use in adult TBI patients and to analyze how this prevalence varies across Level I, Level II, and Level III/IV trauma centers. Methods: A retrospective, multi center cohort study was conducted using data from a statewide trauma registry over a three year period. All adult patients (≥18 years) with a diagnosis of TBI (Abbreviated Injury Scale head region score ≥2) were included. Patients were categorized based on the level of the treating trauma center (Level I, II, or III/IV). The primary outcome was the documented use of any pre injury AC (warfarin, direct oral anticoagulants   DOACs, heparinoids) or AP (aspirin, P2Y12 inhibitors) medication. Secondary analyses examined the specific types of medications, patient demographics, injury severity, and clinical outcomes (in hospital mortality, neurosurgical intervention) across center levels. Results: Among 12,547 TBI patients analyzed, 2,831 (22.6%) were on pre injury AC/AP therapy. Prevalence varied significantly by trauma center level: Level I centers had the highest prevalence at 25.8% (1,250/4,850), followed by Level II at 20.1% (1,020/5,075), and Level III/IV at 21.4% (561/2,622) (p < 0.001). Level I centers treated a significantly higher proportion of patients on DOACs (9.2% vs. 6.5% in Level II and 5.8% in Level III/IV, p<0.001) and had a higher mean patient age. While unadjusted mortality was higher in Level I centers (12.5% vs. 10.8% in Level II and 9.1% in Level III/IV), after adjusting for age, injury severity, and anticoagulant use, the risk adjusted mortality odds were comparable. Patients on AC/AP therapy across all levels had higher mortality and rates of neurosurgical intervention compared to those not on such medications. Conclusion: The prevalence of pre injury anticoagulant and antiplatelet use among TBI patients is substantial and varies systematically across trauma center levels. Level I centers manage a significantly higher burden of patients on these medications, particularly newer DOACs, reflecting patient complexity and referral patterns. These findings underscore the need for all trauma centers, regardless of level, to have protocols for rapid reversal of anticoagulation in TBI, while highlighting that Level I centers require enhanced readiness and resources to manage this high risk population.
Open Access
A Study on the Nursing Effectiveness for Emergency Surgical Trauma Patients
Jingjing Yuan
Jingjing Yuan
Department of Anesthesiology, Perioperative Medicine, and Pain Management, The First Affiliated Hospital of Zhengzhou University, Henan, China
,
Xiangcheng Zhang
Xiangcheng Zhang
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
,
Wei Zhang
Wei Zhang
orthozhang@163.com
The Sixth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China
2026 Jun;1(2):56-61
Background: Nursing care is a critical determinant of outcomes in emergency surgical trauma patients. These patients present with complex, time sensitive needs requiring rapid assessment, coordinated intervention, and comprehensive physiological and psychological support. However, the specific components and overall effectiveness of structured nursing protocols in this high acuity setting require ongoing evaluation. Objective: This study aimed to evaluate the impact of a structured, comprehensive nursing intervention protocol on clinical outcomes, complication rates, and patient/family satisfaction among emergency surgical trauma patients. Methods: A prospective, quasi experimental study was conducted at a Level I trauma center over 18 months. A total of 312 patients requiring emergency surgery for traumatic injuries were allocated into two groups: an Intervention Group (n=156) receiving care under a new, multifaceted nursing protocol (Trauma Nursing Effectiveness Protocol   TNEP), and a Control Group (n=156) receiving standard emergency surgical nursing care. The TNEP emphasized: 1) Triage and primary survey efficiency using a dedicated trauma nurse role, 2) A structured pre operative preparation checklist, 3) Standardized intraoperative handover and warming protocols, and 4) A post operative bundle focusing on early mobilization, pain management, delirium screening, and family engagement. Primary outcomes were time from Emergency Department (ED) arrival to operation, incidence of post operative complications (surgical site infection, pneumonia, deep vein thrombosis), and unplanned ICU readmission within 72 hours. Secondary outcomes included patient reported pain scores, hospital length of stay (LOS), and satisfaction scores from patients and families. Results: The Intervention Group showed significant improvements across multiple metrics. The median time from ED arrival to surgery was reduced by 28 minutes (p<0.01). The composite rate of major post operative complications was 18.6% in the Intervention Group vs. 31.4% in the Control Group (p<0.01), with significant reductions in pneumonia (5.8% vs. 12.8%, p=0.03) and surgical site infection (4.5% vs. 9.6%, p=0.05). Unplanned ICU readmission within 72 hours was lower (3.2% vs. 7.7%, p=0.06). Patients in the Intervention Group reported better pain control at 24 hours post operation (p<0.05), had a shorter median hospital LOS (9 vs. 11 days, p<0.05), and provided significantly higher satisfaction scores regarding communication and overall care experience (p<0.001). Conclusion: The implementation of a structured, comprehensive nursing intervention protocol significantly improves the efficiency of care, reduces post operative complications, and enhances patient satisfaction in emergency surgical trauma patients. This study underscores the vital role of organized, evidence based nursing practices as a key driver of quality and safety in trauma care.
Open Access
Risk Factors for Mortality and the Impact of Targeted Emergency Interventions in Emergency Surgical Trauma Patients
Siti Nurfatimah Mohd Shahpudin
Siti Nurfatimah Mohd Shahpudin
Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia
,
Wei Zhang
Wei Zhang
The Sixth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China
,
Jingjing Yuan
Jingjing Yuan
yjingjing_99@163.com
Department of Anesthesiology, Perioperative Medicine, and Pain Management, The First Affiliated Hospital of Zhengzhou University, Henan, China
2026 Jun;1(2):62-68
Background: Traumatic injury remains a leading cause of death globally, particularly within the first hours after the event. Identifying specific risk factors for mortality in emergency surgical trauma patients and evaluating the efficacy of time sensitive emergency interventions are critical for improving survival. This study aimed to analyze independent predictors of 24 hour and 30 day mortality in patients undergoing emergency trauma surgery and assess the effect of protocolized emergency measures. Methods:  A retrospective analysis was conducted on 2,315 consecutive adult patients who underwent emergency surgical intervention for trauma at a tertiary academic trauma center between January 2020 and December 2023. Data were extracted from electronic health records, surgical logs, and trauma registries. Variables analyzed included demographic data, injury characteristics (mechanism, Injury Severity Score [ISS]), physiological parameters on admission (hypotension, Glasgow Coma Scale [GCS], hypothermia, acidosis), time intervals (pre hospital time, door to operating room), specific interventions (prehospital tourniquet, emergency department thoracotomy [EDT], massive transfusion protocol [MTP] activation), and surgical procedures performed. Primary outcomes were 24 hour and 30 day all cause mortality. Statistical analysis involved univariate comparisons and multivariate logistic regression. Results: The overall 30 day mortality rate was 13.4% (311/2315), with 65.3% of these deaths (203/311) occurring within the first 24 hours. Multivariate analysis identified six independent risk factors for 24 hour mortality: 1) Penetrating trauma to the torso (Adjusted Odds Ratio [aOR] 3.8, 95% CI 2.7–5.4), 2) Admission systolic blood pressure <90 mmHg (aOR 3.5, 95% CI 2.5–4.9), 3) Admission Glasgow Coma Scale score ≤8 (aOR 3.0, 95% CI 2.2–4.2), 4) Injury Severity Score ≥25 (aOR 2.9, 95% CI 2.0–4.1), 5) Presence of concurrent traumatic brain injury and hemorrhagic shock (aOR 6.2, 95% CI 4.1–9.3), and 6) Age ≥65 years (aOR 2.2, 95% CI 1.6–3.1). Protocolized emergency interventions showed a significant protective effect: Activation of an in house Massive Transfusion Protocol within 15 minutes of arrival was associated with a 35% reduction in 24 hour mortality in shocked patients (aOR 0.65, 95% CI 0.48–0.88), and a door to operating room time of <60 minutes for patients in extremis was independently associated with survival (aOR for mortality 0.70, 95% CI 0.52–0.94). Conclusion: Mortality in emergency surgical trauma is multifactorial, with physiological derangement at admission, high energy injury patterns, and advanced age being key non modifiable risk factors. However, mortality can be significantly mitigated by systems based, protocol driven emergency responses, particularly the rapid control of hemorrhage through expedited surgery and goal directed massive transfusion. These findings underscore the vital importance of pre hospital care coordination, in hospital trauma team efficiency, and adherence to time critical surgical and resuscitation protocols.
Open Access
Analysis of the Effects of Surgical Emergency Care and Psychological Nursing Interventions in Traumatic Surgical Patients
Yonggang Peng
Yonggang Peng
The University of Florida, Gainesville, USA
,
Jianhua Xia
Jianhua Xia
Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai, China
,
Xiangcheng Zhang
Xiangcheng Zhang
zhxc0318@163.com
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
2026 Jun;1(2):69-74
Background: Traumatic injuries represent a leading cause of global morbidity and mortality, placing immense demand on emergency healthcare systems. The perioperative period is critical for patient outcomes, requiring not only proficient surgical and emergency nursing care but also attention to the significant psychological distress experienced by patients. Objective: This study aimed to analyze the combined effects of standardized surgical emergency care protocols and structured psychological nursing interventions on clinical outcomes, complication rates, and psychological well being in patients undergoing emergency surgery for trauma. Methods: A prospective cohort study was conducted involving 120 traumatic surgical patients admitted to the emergency department. Participants were systematically allocated into an intervention group (n=60) receiving integrated standardized surgical emergency care plus targeted psychological nursing interventions, and a control group (n=60) receiving standard surgical emergency care alone. Clinical parameters (vital sign stability, time to surgery, complication rates), physiological indicators (pain scores, cortisol levels), and psychological metrics (Hospital Anxiety and Depression Scale   HADS, Post Traumatic Stress Disorder Checklist   PCL 5) were assessed at admission, pre operatively, post operatively (24h, 72h), and at one month follow up. Results: The intervention group demonstrated statistically significant improvements compared to the control group. Key findings included enhanced hemodynamic stability pre operatively (p<0.01), reduced mean time from admission to operation (p<0.05), lower incidence of post operative complications such as infection and delirium (15% vs. 31.7%, p<0.05), and significantly lower reported pain scores at 24h post operation (p<0.01). Psychologically, the intervention group showed markedly lower HADS scores for anxiety and depression at 72h post operation and at one month follow up (p<0.001), as well as lower PCL 5 scores indicative of reduced PTSD symptom severity (p<0.01). Patient satisfaction scores were also significantly higher in the intervention group (p<0.001). Conclusion: The integration of structured psychological nursing interventions with standard surgical emergency care protocols significantly improves both physiological and psychological outcomes in traumatic surgical patients. This dual approach facilitates smoother perioperative transitions, reduces complications, alleviates psychological distress, and promotes long term recovery. These findings underscore the necessity of incorporating psychological support as a core component of holistic trauma care protocols.
Open Access
The Limited Role of Emergency Department Thoracoscopy in Penetrating Neck Trauma
Jie Fan
Jie Fan
University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.
,
Jianhua Xia
Jianhua Xia
Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai, China
,
Xiangcheng Zhang
Xiangcheng Zhang
zhxc0318@163.com
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
2026 Jun;1(2):75-80

Background: Penetrating neck trauma (PNT) represents a surgical emergency due to the potential for life threatening vascular and aerodigestive injuries. Traditional management relies on physical examination, advanced imaging (e.g., CT angiography), and mandatory surgical exploration in selected cases. Video assisted thoracoscopic surgery (VATS), while established in elective thoracic surgery, has been proposed as a potential tool for rapid assessment in the emergency department (ED) or trauma bay setting for injuries with suspected intrathoracic extension. However, its utility, feasibility, and impact on outcomes in the acute management of PNT remain poorly defined and potentially limited. Objective: This study aimed to critically evaluate the role, diagnostic yield, and therapeutic impact of emergency department thoracoscopy (ED VATS) in the management of hemodynamically stable patients with penetrating neck trauma, and to compare outcomes with a standard management protocol. Methods: A retrospective cohort study was conducted at a Level I trauma center over a 5 year period. Patients with PNT (zones I III) who were hemodynamically stable on presentation were included. Two groups were compared: 1) The ED VATS Group: patients who underwent thoracoscopy in the ED or trauma resuscitation room for suspected intrathoracic injury (e.g., based on wound trajectory, chest X ray findings, or ultrasound). 2) The Standard Management Group: patients managed per protocol with a combination of physical exam, multi detector computed tomography angiography (MDCTA), endoscopic evaluation, and observation or operative exploration as indicated. Primary outcomes were diagnostic accuracy of ED VATS for thoracic injuries, rates of negative/non therapeutic procedures, time to definitive management, and in hospital complications. Results: Of 347 patients with PNT, 28 (8.1%) underwent ED VATS, while 319 were managed with the standard protocol. The diagnostic yield of ED VATS for a clinically significant intrathoracic injury (requiring intervention) was only 39.3% (11/28). In 17 patients (60.7%), ED VATS was non diagnostic or identified minor injuries not requiring intervention. The median time from ED arrival to incision for ED VATS was 42 minutes, but 9 patients (32.1%) in this group subsequently required a formal operative intervention (thoracotomy or neck exploration) based on VATS findings or clinical progression, effectively adding a procedural step. Compared to the standard group, the ED VATS group had no significant difference in mortality (3.6% vs. 2.5%, p=0.6) or major complication rates (14.3% vs. 11.9%, p=0.7), but had a significantly higher rate of minor complications related to the procedure (e.g., port site issues, prolonged air leak) (21.4% vs. 3.1%, p<0.001). MDCTA demonstrated a sensitivity of 98% and specificity of 95% for detecting injuries requiring intervention. Conclusion: In hemodynamically stable patients with penetrating neck trauma, emergency department thoracoscopy has a limited and highly selective role. It carries a high rate of non therapeutic procedures, adds minimal therapeutic benefit over modern imaging guided selective management, and introduces procedure specific morbidity. Its use should be restricted to rare, specific scenarios where immediate thoracic visualization is deemed critical and CT is contraindicated or unavailable, rather than as a routine diagnostic tool. Standardized protocols utilizing clinical examination and MDCTA remain the cornerstone of safe and effective management.

Open Access
Readmission Patterns in the Intensive Care Unit of a Level I Trauma Center
Xiangcheng Zhang
Xiangcheng Zhang
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
,
Siti Nurfatimah Mohd Shahpudin
Siti Nurfatimah Mohd Shahpudin
Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia
,
Jie Fan
Jie Fan
jif7@pitt.edu
University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.
2026 Jun;1(2):81-86
Background: Readmission to the Intensive Care Unit (ICU) is a significant adverse event associated with increased mortality, prolonged hospital length of stay (LOS), and higher healthcare costs. While general ICU readmission rates and predictors are well studied, the specific context of a Level I Trauma Center ICU—characterized by a unique, acutely injured, and heterogeneous patient population—requires focused analysis. Objective: This study aims to determine the incidence, timing, primary causes, and independent risk factors associated with ICU readmission within the same hospitalization for patients in a Level I Trauma Center ICU, and to evaluate its impact on patient outcomes. Methods: A retrospective cohort study was conducted over a three year period at the Level I Trauma Center of a major academic hospital. All adult patients (≥18 years) admitted to the trauma ICU (TICU) were included. Data were extracted from the institutional trauma registry and electronic health records. Patients who were readmitted to the TICU (case group) were compared with those who had a single, continuous TICU stay (control group). Analyzed variables included demographics, injury characteristics (ISS, AIS, mechanism), pre existing comorbidities, physiological and laboratory data at initial ICU discharge, processes of care (timing of discharge, nurse to patient ratio), and outcomes (mortality, total LOS, ICU LOS). Multivariable logistic regression was used to identify independent predictors of ICU readmission. Results: Of 4,217 initial TICU admissions, 178 (4.2%) required readmission. The median time to readmission was 3 days (IQR: 2 5 days). The leading causes for readmission were respiratory failure (32.6%), neurological deterioration (24.7%), and sepsis/septic shock (18.5%). Independent risk factors for readmission included: higher Injury Severity Score (ISS) (OR 1.03 per point, 95% CI 1.01 1.05), severe traumatic brain injury (AIS head ≥3) (OR 2.1, 95% CI 1.5 3.0), pre existing chronic obstructive pulmonary disease (COPD) (OR 2.3, 95% CI 1.4 3.7), and discharge from the ICU during night shifts (20:00 08:00) (OR 1.8, 95% CI 1.2 2.7). Patients with ICU readmission had significantly higher in hospital mortality (15.2% vs. 6.1%, p<0.001), longer median total hospital LOS (28 vs. 14 days, p<0.001), and longer cumulative ICU LOS (12 vs. 5 days, p<0.001). Conclusion: ICU readmission in a Level I Trauma Center is a relatively frequent occurrence associated with markedly worse outcomes. It is strongly linked to injury severity, specific injury patterns (TBI), underlying comorbidities (COPD), and potentially modifiable system factors like night time discharge. These findings highlight the need for tailored discharge planning, enhanced monitoring of high risk patients, and protocolized weaning and handover processes to mitigate this critical quality metric.
Open Access
The Impact of Structured Anti Infective Nursing Care on Outcomes in Emergency Surgical Trauma Patients: A Quasi Experimental Study
Xiangcheng Zhang
Xiangcheng Zhang
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
,
Yonggang Peng
Yonggang Peng
The University of Florida, Gainesville, USA
,
Leng Fei
Leng Fei
lengf@bch.edu.cn
Beijing Children's Hospital, Capital Medical University, Beijing, China
2026 Jun;1(2):87-92
Background: Sepsis and surgical site infections (SSIs) are major causes of morbidity and mortality following traumatic injury. While prompt surgical intervention and antibiotics are critical, the role of protocolized, nurse driven anti infective care in the emergency setting remains underexplored. This study evaluated the effectiveness of a structured, multi component anti infective nursing bundle on clinical outcomes in emergency surgical trauma patients. Methods: A quasi experimental, pre post intervention study was conducted at a Level I trauma center. The control group consisted of 415 patients admitted between July and December 2022, receiving standard care. The intervention group consisted of 428 patients admitted between January and June 2023, managed with a novel "TIME" nursing bundle: Timely administration of antibiotics and cultures, Intensive metabolic control (glycemic & temperature), Meticulous wound and catheter care, and Early source control coordination. Primary outcomes were the incidence of sepsis within 72 hours and SSI within 30 days. Secondary outcomes included antibiotic days, length of ICU stay, and 30 day mortality. Data were analyzed using chi square tests, t tests, and multivariate logistic regression. Results: Implementation of the TIME bundle was associated with significant improvements. The sepsis rate decreased from 18.1% to 11.0% (p<0.01), and the SSI rate decreased from 12.3% to 7.0% (p<0.01). Patients in the intervention group had fewer mean antibiotic days (5.2 vs. 7.8, p<0.01), shorter ICU stays (4.5 vs. 6.1 days, p<0.05), and lower 30 day mortality (8.6% vs. 12.8%, p<0.05). After adjusting for injury severity, the TIME bundle was an independent protective factor against sepsis (aOR 0.52, 95% CI 0.34 0.79) and SSI (aOR 0.49, 95% CI 0.30 0.80). Conclusion: A structured, nurse led anti infective care bundle significantly reduced the incidence of early sepsis and surgical site infections in emergency trauma surgery patients, and was associated with improved antibiotic stewardship and clinical outcomes. These findings highlight the pivotal role of targeted nursing interventions in the multidisciplinary effort to prevent infections in trauma care.
Open Access
The Impact of Different Transfusion Strategies on Coagulation Function and Blood Resource Utilization in Surgical Trauma Patients with Major Hemorrhage
Wei Zhang
Wei Zhang
The Sixth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China
,
Leng Fei
Leng Fei
Beijing Children's Hospital, Capital Medical University, Beijing, China
,
Siti Nurfatimah Mohd Shahpudin
Siti Nurfatimah Mohd Shahpudin
sitinurfatimah.ms@usm.my
Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia
2026 Jun;1(2):93-98
Background: Major hemorrhage in surgical trauma patients presents a complex challenge, where transfusion strategies significantly influence both patient outcomes and resource stewardship. The optimal ratio of blood components particularly packed red blood cells (PRBCs), fresh frozen plasma (FFP), and platelets remains a critical area of investigation. Balanced transfusion approaches (e.g., 1:1:1 ratios) aim to correct trauma induced coagulopathy early but may increase blood product usage. Conversely, restrictive or guided strategies might conserve resources but risk inadequate hemostatic support. Objective: This study aimed to compare the effects of a balanced transfusion strategy versus a viscoelastic hemostatic assay (VHA) guided strategy on coagulation function, blood product consumption, and clinical outcomes in surgical trauma patients with major hemorrhage. Methods: A prospective, randomized controlled trial was conducted at a Level I trauma center. Adult patients with major traumatic hemorrhage requiring massive transfusion protocol (MTP) activation were randomized to: 1) Balanced Group: receiving PRBC:FFP:platelets in a 1:1:1 ratio until MTP was terminated, or 2) VHA Guided Group: where transfusion of FFP, platelets, and fibrinogen concentrate was directed by real time thromboelastometry (ROTEM®). Primary outcomes were the proportion of patients achieving hemostatic competence (defined as stable clot formation on ROTEM and controlled surgical bleeding) within 6 hours, and total units of allogeneic blood products transfused in the first 24 hours. Secondary outcomes included mortality (24 hour, 30 day), incidence of thromboembolic events, multiple organ dysfunction syndrome (MODS), and ICU length of stay. Results: 120 patients were randomized (60 per group). The VHA guided group achieved hemostatic competence significantly faster than the balanced group (median 2.8 vs. 4.1 hours, p<0.01) and received 35% fewer total units of allogeneic blood products in the first 24 hours (median 18 vs. 28 units, p<0.001). This reduction was primarily driven by significantly lower use of FFP and platelets. There was no significant difference in 24 hour mortality (8.3% vs. 11.7%, p=0.53) or 30 day mortality (20.0% vs. 23.3%, p=0.66). However, the VHA guided group had a lower incidence of MODS (18.3% vs. 33.3%, p=0.048) and a non significant trend towards fewer thromboembolic events (5.0% vs. 11.7%, p=0.18). Conclusion: In surgical trauma patients with major hemorrhage, a ROTEM guided transfusion strategy, compared to a fixed ratio balanced strategy, leads to more rapid correction of coagulopathy with significantly reduced consumption of plasma and platelet components, without compromising survival. This targeted approach optimizes coagulation function while promoting efficient blood resource utilization, supporting its integration into trauma resuscitation protocols.
Open Access
Incidence and Risk Factors for Surgical Site Infection Following General Trauma Surgery: A Retrospective Cohort Analysis
Jie Fan
Jie Fan
University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.
,
Siti Nurfatimah Mohd Shahpudin
Siti Nurfatimah Mohd Shahpudin
Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia
,
Xiangcheng Zhang
Xiangcheng Zhang
zhxc0318@163.com
Department of Critical Care Medicine, Huai'an First People's Hospital, Huai'an, China
2026 Jun;1(2):99-105
Background: Surgical site infection (SSI) remains a significant and costly complication after trauma surgery, contributing to increased morbidity, prolonged hospitalization, and higher healthcare expenditures. Identifying the incidence and modifiable risk factors specific to the general trauma surgery population is essential for developing targeted prevention strategies. Methods: A single center retrospective cohort study was conducted. We included 2,134 adult patients who underwent emergency general trauma surgery (e.g., laparotomy, thoracotomy, repair of major fractures with soft tissue involvement) between January 2018 and December 2022. SSI was defined and classified according to the Centers for Disease Control and Prevention (CDC) criteria. Patient demographics, injury characteristics, operative details, and perioperative management data were collected. Univariate analyses and multivariate logistic regression were performed to identify independent predictors of SSI. Results: The overall incidence of SSI was 9.2% (197/2134). Superficial incisional SSI accounted for 5.6%, deep incisional SSI for 2.5%, and organ/space SSI for 1.1%. Multivariate analysis identified six independent risk factors: open fracture (Gustilo type III) or gross intra abdominal contamination at injury (adjusted odds ratio [aOR] 3.71, 95% confidence interval [CI] 2.54 5.42), surgery duration >180 minutes (aOR 2.95, 95% CI 2.05 4.25), requirement for massive transfusion (>10 units of packed red blood cells in 24 hours) (aOR 2.73, 95% CI 1.88 3.96), preoperative hypothermia (core temperature <36.0°C) (aOR 2.41, 95% CI 1.68 3.46), diabetes mellitus (aOR 2.02, 95% CI 1.39 2.93), and body mass index (BMI) ≥30 kg/m² (aOR 1.78, 95% CI 1.23 2.58). Appropriate preoperative antibiotic prophylaxis (administered within 60 minutes before incision) was a significant protective factor (aOR 0.38, 95% CI 0.26 0.56). Conclusion: SSI complicates nearly one in ten general trauma surgeries, with several strong and potentially modifiable risk factors. These findings underscore the importance of protocolized care bundles addressing timely antibiotic administration, normothermia maintenance, blood conservation strategies, and consideration of damage control surgery in high risk patients to reduce the burden of SSI.
Journal of Contemporary Surgical Science
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