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DOI: https://doi.org/10.61189/905466eqluyw
Endless possibilities in academia
Endless possibilities in academia
Chenglong Zhu1, Jianhua Xia2, Zui Zou1
1School of Anesthesiology, Naval Medical University, Shanghai 200433, China.2Department of Anesthesiology, Shanghai Pudong New Area People's Hospital, Shanghai 201200, China.
Address correspondence to: Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China. E-mail: zouzui@smmu.edu.cn.
DOI: https://doi.org/10.61189/905466eqluyw
Received October 26, 2024; Accepted January 7, 2025; Published June 30, 2025
Difficult airways are a common concern for physicians in the department of anesthesiology, emergency medicine, and critical care medicine. SEEKflex (Safe Easy Endotracheal kit-flexible) is a novel multifunctional introducer developed by our team to address difficult airways. It has been registered as a medical device in China (Zhejiang Medical Device Registration Approval No. 20232081322).
The SEEKflex system features a dual-component design, consisting of a primary introducer and a supplementary adapter. With an outer diameter of 4.0 mm and an inner diameter of 2.4 mm, it is compatible with tracheal tubes of an internal diameter exceeding 4.5 mm. The introducer, extending from 43 to 81 cm, is equipped with a flexible steel core for guidance and a smooth polyvinyl chloride (PVC) sheath. This assembly can be securely fastened using a blue locking mechanism, as depicted in Figure 1A-B [1].
SEEKflex can be bent at an appropriate angle due to the malleability of its inner core, allowing it to be easily inserted into the trachea just under the epiglottis in cases of unpredicted difficult airway (Cormack-Lehane Grade III). This procedure is facilitated by a video laryngoscope. The endotracheal position of SEEKflex is confirmed by connecting it to an EtCO2 monitor via the adapter after removing the inner core (Figure 1C). The endotracheal tube can be easily advanced into the trachea using the Seldinger technique, with the guidance of reconnected, post-stretching SEEKflex. In addition, we have developed a “12-step” approach for awake tracheal intubation using SEEKflex and a video laryngoscope, which has yielded satisfactory clinical results [2].
At the distal end of the outer catheter, there is one vent at the top and 4 rows of lateral vents. After removing the inner core and attaching the adapter, local anesthetic can be administrated, and oxygenation can be maintained using a ventilator, like a slender tracheal tube. The original version of this introducer was used for reintubation of COVID-19 patients, and the outer catheter could be left in place for subglottic oxygenation after extubation [3]. This feature is also used for oxygenation maintenance and tracheal intubation in emergency situations during bronchoscopic balloon dilation [4].
Several randomized controlled studies, approved by the Ethics Committee of the Naval Medical University and currently in the process of data collection, may further provide robust evidence of its safety and efficacy. We believe that this new multifunctional introducer can be widely adopted by anesthesiologists due to its versatility across multiple clinical scenarios.
Letter to the Editor |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 39-40
Tian Zhou1, Chenglong Zhu1, Feixiang Wu2, Xingzhi Liao3, Wenyun Xu4, Hui Chen5, Jinlong Qu6, Jinfei Shi7, Yaohua Yu8, Ying Huang9, Miao Zhou10, Hua Tang11, Shengyun Cai12, Wenchao Gao13, Zui Zou1
1School of Anesthesiology, Naval Medical University, Shanghai, 200433, China. 2Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. 3Department of Anesthesiology, The 904th Hospital of the Logistics Support Force of the Chinese People's Liberation Army, Wuxi 214044, Jiangsu Province, China. 4Department of Anesthesiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. 5Department of Anesthesiology and Perioperative medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China. 6Department of Emergency and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China. 7Department of Anesthesiology, Anhui Provincial Hospital of the Armed Police, Hefei 230001, Anhui Province, China. 8Department of Anesthesiology, The First Hospital of Putian City, Putian 351100, Fujian Province, China. 9Department of Intensive Care Unit, the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China. 10Department of Anesthesiology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University, Nanjing 210009, Jiangsu Province, China. 11Department of Thoracic Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China. 12Department of Obstetrics and Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China. 13Department of Colorectal Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Address correspondence to: Shengyun Cai, Department of Obstetrics and Gynecology, First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China. Email: caicai24@126.com. Wenchao Gao, Department of Colorectal Surgery, Second Affiliated Hospital of Naval Medical University, 415 Fengyang Road, Shanghai 200003, China. Email: gaowenchao2007@163.com. Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Shanghai 200433, China. Email: zouzui@smmu.edu.cn.
Acknowledgement: This study was funded by the following projects: Shanghai Industrial Collaborative Innovation Project (HCXBCY - 2023 – 041, XTCX - KJ - 2024 - 39, HCXBCY - 2024 – 033), 2024 Basic Medicine Innovation Open Topic (JCKFKT - MS - 002), and the 2024 Annual Pharmaceutical Science and Technology Key Research Project of the China Medicine Education Association (2024KTZ011).
DOI: https://doi.org/10.61189/707615erclry
Received February 20, 2025; Accepted February 24, 2025; Published June 30, 2025
Expert Consensus |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 41-47
Mingling Wang1, Lien Qi1, Kai Wang2, Jing Zhang3, Xiaoyan Wang1
Departments of 1Operating Room, 2Anesthesiology, 3Nursing, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China.
Address correspondence to: Xiaoyan Wang, Department of Operating Room, Xuzhou Central Hospital, Jiefang South Road, No. 199, Xuzhou 221009, Jiangsu Province, China. Tel: +86-15351687352; E-mail: 531446635@qq.com; Jing Zhang, Department of Nursing, Xuzhou Central Hospital, Jiefang South Road, No. 199, Xuzhou 221009, Jiangsu Province, China. Tel: +86-18012018586; E-mail: 2038634928@qq.com.
Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Committee of Xuzhou Central Hospital (approval no. XZXY-LK-20220114-027) and conducted in accordance with the ethical principles for medical research involving human subjects described in the Declaration of Helsinki. Prior to inclusion in this study, informed consent was obtained from all participants. Trial Registration clinicaltrials.gov Identifier: CTR20200708.
DOI: https://doi.org/10.61189/082747tokokd
Received July 8, 2024; Accepted September 3, 2024; Published June 30, 2025
Highlights
● Gastrointestinal decompression (GID) near the gastric body reduces nausea, vomiting, and discomfort.
● GID near the gastric body is conducive to exposure of the operative space.
● GID near the gastric body improves postoperative recovery of gastrointestinal function.
Research Article |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 48-53
Wenxin Shi, Yajun Hu, Jin Lan, Jun Xiong, Zhiyong Li
Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.
Address correspondence to: Jun Xiong, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: xiongjun2001@163.com; Zhiyong Li, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: zhiyongli@smmu.edu.cn.
Acknowledgement: This work was supported by grants from the Shanghai Science (23ZR1477400) and Technology Commission Project (201409004600).
DOI: https://doi.org/10.61189/629158xrbqam
Received October 28, 2024; Accepted January 7, 2025; Published June 30, 2025
Highlights
● Intestinal barrier dysfunction increases the risk of perioperative complications.
● The immunologic barrier is crucial for maintaining intestinal homeostasis.
● Perioperative factors compromise the intestinal immunologic barrier, increasing infection risk.
● An imbalance between intestinal microbiota and immune cells affects postoperative recovery.
● Clinical intervention studies targeting the intestinal barrier are summarized.
Review Article |Published on: 30 June 2025
[Perioperative Precision Medicine] 2025; 3 (2): 54-70
