Objective: To evaluate the clinical effect of comfort nursing intervention in preventing incontinent-associated der matitis (IAD) and related complications in critically ill patients. Methods: This study enrolled critically ill patients from the Intensive Care Unit at Ningxiang People’s Hospital between June 2020 and June 2024. Patients were randomly assigned to a comfort nursing group (n=51) and a routine nursing group (n=53). The comfort nursing group received comprehensive comfort nursing, while the routine nursing group received standard care. The in cidence, classification and area of IAD as well as the incidence of complications and patient / family satisfaction with nursing care, were assessed. Results: The incidence of IAD was significantly lower in the comfort nursing group (8 patients) compared to the routine nursing group (21 patients) (P<0.05). Additionally, the incidences of wound infection and muscle soreness were notably lower in the comfort nursing group (both P<0.05). Patient and family satisfaction in the comfort nursing group was significantly higher than in the routine nursing group (both P<0.05). Conclusion: Comfort nursing intervention is effective in preventing IAD and reducing associated compli cations in critically ill patients, thereby improving patient and family satisfaction with treatment.