Objective: To explore the effect of evidence-based care on lower-limb thrombosis and negative emotions following hip arthroplasty. Methods: A total of 108 patients undergoing hip arthroplasty at our hospital were randomly assigned to the observation group (n=54, evidence-based care) and the control group (n=54, conventional care). Postoperative complications, negative emotions, quality of life, activities of daily living, and patient satisfaction were compared between the two groups. Results: The observation group had a lower incidence of lower-limb thrombosis and overall complications, as well as higher patient satisfaction than the control group (all P<0.05). One month after discharge, patients in the observation group showed significantly lower scores on the Hamilton Anxiety Scale, the Hamilton Depression Scale, and activities of daily living scale, but with increased Generic Quality of Life Inventory-74 scores, compared with before intervention (all P<0.05). Conclusion: Evidence-based care significantly relieves anxiety and depression, reduces the incidence of lower-limb thrombosis, and improves quality of life in patients after hip arthroplasty.