Chenglong Zhu^1,3*, Miao Zhou^1,4*, Yongchu Hu², Wenyun Xu², Zui Zou^1,2

¹School of Anesthesiology, Naval Medical University, Shanghai 200433, China. ²Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. ³Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. ⁴Department of Anesthesiology, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University, Nanjing 210009, Jiangsu, China. 

*The authors have contributed equally to this work. 

Address correspondence to: Zui Zou, School of Anesthesiology, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China. Email: zouzui@smmu.edu.cn. Wenyun Xu, Second Affiliated Hospital of Naval Medical University, 415 Fengyang Road, Huangpu District, Shanghai 200003, China. Email: xuwenyun@ smmu.edu.cn.

Acknowledgement: This study was funded by the National Natural Science Foundation of China (81670072), the Shanghai Municipal Committee of Science and Technology (20XD1434400) and Special Project on Incubation of Civil-Military Integration Achievements of the Naval Medical University (2022-RH10). Declaration of conflict of interest: None. 

Ethics approval and consent to participate: Chinese Clinical Trial Registry approved this study (ChiCTR2200060783). All procedures and research activities performed in the study were in accordance with the ethical standards of the institutional research committee. Consent was obtained from a legally authorized representative. 

DOI: https://doi.org/10.61189/109678mkmeds

Received November 29, 2023; Accepted January 16, 2024; Published June 30, 2024

Highlights 

● SEEK^flex (Safe Easy Endotracheal Kit-flexible) is a modified introducer, which provides a simple and rapid way for intubating patients with laryngeal tumors. 

● With its non-invasive and gentle approach, SEEK^flex minimizes patient discomfort, enhancing the overall patient experience. 

● Flexible fiberoptic bronchoscope remains the most frequently used tool for managing difficult airways.

Huanjia Xue^1,3, Shengze Yang^2,3, Guangkuo Ma^1,3, Ziwei Xia^1,3, Liwei Wang^1,3, Kai Wang ^1,3

¹Xuzhou Clinical College, ²School of Anesthesiology, Xuzhou Medical University, Xuzhou 221009, China. ³Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, China.

Address correspondence to: Kai Wang, Department of Anesthesiology, Xuzhou Central Hospital, No.199 Jiefang South Road, Quanshan District, Xuzhou 221009, Jiangsu, China. Tel: 18112012729. E-mail: wangkaistream99@ xzhmu.edu.cn.

Acknowledgement: This work was supported by Young Scientist Fund of National Natural Science Foundation of China (81700078) and Xuzhou Medical Key Talents program (XWRCHT20220051).

DOI: https://doi.org/10.61189/601268tfpowt

Received November 5, 2023; Accepted January 30, 2024; Published June 30, 2024

Highlights

● Foot and ankle arthroscopic techniques are vital for diagnosing and treating foot and ankle disorders.

● Ultrasound-guided nerve blocks in the foot and ankle provide precise nerve selection.

Ziyue Li¹, Bailong Hu², Xiaohua Zou²

¹College of Anesthesiology, Guizhou Medical University, Guizhou 550004, China. ²Department of Anesthesiology, the Affiliated Hospital of Guizhou Medical University, Guizhou 550004, China. 

Address correspondence to: Bailong Hu, Department of Anesthesiology, the Affiliated Hospital of Guizhou Medical University, NO. 28 Guiyi Street, Guiyang 550004, Guizhou, China. Phone number: +86-15185184309; E-mail: hubailong@gmc.edu.cn. Xiaohua Zou, Department of Anesthesiology, the Affiliated Hospital of Guizhou Medical University, NO. 28 Guiyi Street, Guiyang 550004, Guizhou, China. Tel: +86-13809416036; Fax: +86-851-86771013; E-mail: zouxiaohuazxh@gmc.edu.cn.

Acknowledgement: This work was supported by the National Natural Science Foundation of China (No. 82160951, 82160224), the project of Guiyang Science and Technology Plan (zhukehe[2024]-2-27), the Cultivate project 2021 for National Natural Science Foundation of China, the Affiliated Hospital of Guizhou Medical University (gyfynsfc-2021-35, gyfynsfc-2021-49).

DOI: https://doi.org/10.61189/434706ysltap

Received December 5, 2023; Accepted February 4, 2024; Published June 30, 2024

Highlights 

Currently, ischemic heart disease ranks as the most prevalent form of primary heart disease. The risk of myocardial ischemia-reperfusion injury, along with its associated mortality, is notably rising among perioperative patients. Recognizing the underlying mechanisms of myocardial ischemia-reperfusion injury and identifying suitable treatments are crucial. Inhibitors targeting the key molecules involved in pyroptosis hold promise as potential therapeutic options for managing myocardial ischemia-reperfusion injury

Yangmengna Gao^1,2, Ran Yuan^1,2, Kecheng Zhai^1,2, Hui Su^1,2, Renke Sun^1,2, Shangping Fang^1,2 

¹School of Anesthesiology, ²Anesthesia Laboratory and Training Center, Wannan Medical College, Wuhu 241002, Anhui, China. 

Address correspondence to: Shangping Fang, Anaesthesiology Experimental Training Center, College of Anesthesiology, Wannan Medical College, No.22 Wenchang West Road, Yijiang District, Wuhu 241002, Anhui, China. Tel:+86-19855362767. E-mail: 20180041@wnmc.edu.cn.

Acknowledgement: Key Project Research Fund of Wannan Medical College (WK2022Z10); National College Student Innovation and Entrepreneurship Project (202310368016); Anhui Province College Student Innovation and Entrepreneurship Project (S202210368107, S202210368108); Student Research Funding Project of Wannan Medical College (WK2023XS10).

DOI: https://doi.org/10.61189/076009mwdtns

Received January 25, 2024; Accepted March 19, 2024; Published Jane 30, 2024

Highlights 

● Sphingosine 1-phosphate receptor 3 (S1PR3) promotes the proliferation of vascular endothelial cells and enhances barrier function. 

● S1PR3 is a promising target for clinical treatment of cardiac ischemia-reperfusion, cardiac fibrosis and atherosclerosis. 

● Fingolimod and other modulators of S1PR3 have shown therapeutic efficacy in phase I and II clinical trials for cardiovascular diseases. 

● S1PR3 play crucial roles in the perioperative evaluation and treatment of the cardiovascular system, as well as in sepsis.