Gene therapy holds immense potential for treating genetic skin disorders such as epidermolysis bullosa and psoriasis. However, the delivery of nucleic acids (DNA, siRNA, mRNA) remains a significant challenge due to their instability and poor skin permeation. Nanocarrier-based systems, including lipid nanoparticles (LNPs) and polymeric nanoparticles, offer a promising solution by protecting nucleic acids and facilitating their targeted delivery to skin cells. This review explores the design, mechanisms, and clinical applications of nanocarriers in gene therapy for skin disorders, highlighting their potential to revolutionize treatment paradigms.