Skin infections, caused by bacteria, fungi, and viruses, pose significant clinical challenges due to the barrier function of the stratum corneum and the rise of antimicrobial resistance. Nanocarrier-based delivery systems, including liposomes, solid lipid nanoparticles (SLNs), and polymeric nanoparticles, offer a promising solution by enhancing drug penetration, stability, and targeted delivery. This review explores the design, mechanisms, and clinical applications of nanocarriers in delivering antimicrobial agents for skin infections, highlighting their potential to overcome resistance and improve therapeutic outcomes.