Lipid-Based Nanocarriers for Enhanced Topical and Transdermal Drug Delivery-ZENTIME PUBLISHING CORPORATION LIMITED

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Lipid-Based Nanocarriers for Enhanced Topical and Transdermal Drug Delivery

Yuehong Xu¹, Quangang Zhu², Nianping Feng³^*

¹ Sun Yat-Sen University, Guangzhou 510275, China
² Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China
³ Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Corresponding Author:Nianping Feng, Email: npfeng@shutcm.edu.cn

Abstract

Lipid-based nanocarriers, including liposomes, ethosomes, and solid lipid nanoparticles (SLNs), have revolutionized topical and transdermal drug delivery by enhancing skin permeation and bioavailability. This review explores the design, mechanisms, and clinical applications of these systems, focusing on their ability to encapsulate both hydrophilic and lipophilic drugs. Advances in surface modification and stimuli-responsive strategies are also discussed, highlighting their potential for personalized dermatotherapy.

Keywords: Lipid Nanocarriers; Topical Delivery; Transdermal Delivery; Skin Permeation; Nanotechnology

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