Hydrogels have emerged as versatile platforms for drug delivery in wound healing and dermatological repair due to their high water content, biocompatibility, and ability to provide a moist wound environment. This review explores the design, mechanisms, and clinical applications of hydrogel-based systems, focusing on their role in delivering growth factors, antimicrobials, and anti-inflammatory agents. Advances in stimuli-responsive hydrogels and their integration with nanotechnology are also discussed, highlighting their potential for personalized wound care.