Application and progress of functionalized magnetic bead-based biosensors for protein detection-ZENTIME PUBLISHING CORPORATION LIMITED

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Application and progress of functionalized magnetic bead-based biosensors for protein detection

Haoyuan Su¹, Yuehua Liao², Shu Wu¹, Jun Ji¹, Shuya An¹, Dongdong Zeng²

¹School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; ²School of Medical device, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.

Address correspondence to: Dongdong Zeng, School of Medical device, Shanghai University of Medicine & Health Sciences, No. 268 Zhouzhu Highway, Pudong, Shanghai 201318, China. E-mail: zengdd@sumhs.edu.cn.

DOI: https://doi.org/10.61189/403384jfzmyx

Highlights

● In the field of bioanalysis, a new biosensor technology based on functionalized magnetic beads is leading a new direction in protein detection. With its excellent separation efficiency and sensitivity, it provides a powerful tool for early disease diagnosis and biomarker monitoring.
● This article explores the latest advancements in this technology, including innovative magnetic bead designs, diverse detection strategies, and the technical challenges and future development directions. It reveals the potential and application prospects of biosensor technology in biomarker detection.

Abstract

In the field of bioanalysis, the integration of magnetic beads and biosensors provides a protein detection platform with high separation efficiency and sensitivity. The superparamagnetism of magnetic beads, combined with surface functional modifications, forms the basis for selectively capturing and effectively separating target proteins. Additionally, the high sensitivity and specificity of biosensors ensure precise quantitative analysis of captured proteins. This article systematically reviews the synthesis strategies of functionalized magnetic beads, detection methods for proteins and nucleic acids, as well as the current technical challenges and future development directions.

Keywords: Protein, magnetic beads, biosensor

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