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Progress on Microfluidic Blood Cell Counting Techniques

Yongqian Zhang, Weifeng  Wu, Qianfeng Xu, Yunsheng Zhong, Rongguo Yan


School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.


Address correspondence to: Rongguo Yan, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. E-mail: yanrongguo@usst.edu.cn. 


Received December 26, 2022; Accepted April 6, 2023; Published June 30, 2023


DOI: https://doi.org/10.61189/373860nqgwfq


Highlights

The paper introduces three commonly used blood cell counting techniques, electrical impedance method, light scattering method and microscopic imaging method based on microfluidic chips, as well as their latest research progress.

Abstract

Accurately and efficiently detecting the quantity of blood cells is crucial in routine blood examination, as abnormal high or low numbers of blood cells are associated with the occurrence of various disorders. Due to inherent drawbacks, traditional blood cell analysis equipment cannot meet the demands of modern primary healthcare, particularly in terms of point-of-care testing. In recent years, the development of point-of-care testing blood cell counting equipment has been accelerated, thanks to the rapid advancement of microfluidic technology and the expanding research on blood cell counting using microfluidic chips. In this paper, we reviewed three blood cell counting methods based on microfluidic chips, electrical impedance, light scattering, and microscopic imaging, as well as the recent development and achievements in blood cell counting using microfluidic chips.

Keywords: Blood cell counting, microfluidic chip, electrical impedance method, light scattering method, microscop-ic imaging method


Zhang YQ, Wu FF, Xu QF, et al. Progress on Microfluidic Blood Cell Counting Techniques. Prog in Med Devices. 2023 Jun;1(1):2-9. doi: 10.61189/373860nqgwfq. 
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