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Science Immunity & Inflammation Reviews is an open-access, peer-reviewed international journal that publishes authoritative review articles, comments, perspectives, and other scholarly formats that introduce advances across the entire spectrum of immunology and inflammation research. It serves as a unifying platform for interdisciplinary academic exchange, bridging molecular mechanisms, cellular biology, clinical translation, and therapeutic innovation. Areas of focus include but are not limited to, innate and adaptive immunity, autoimmunity, chronic inflammation, infection-induced immune responses, immunometabolism, neuroimmune interactions, and immunotherapy.

Lastest Issue

Advances and Future Directions in Immunotherapy for Lung Cancer

Li Wang1,2, Liping Zhang2, Yi Yang1,2,3

1Biotherapy Center, 2Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China; 3School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China

Address correspondence to: Dr. Yi Yang, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China. Tel: +86 371 66295420; E-mail: yiyang@zzu.edu. cn

Inflammatory Cytokine Responses in Pediatric Malaria Cases in Franceville, Gabon

Sandrine Lydie Bouopda-Tuedom1, Lady Charlène Nzoughe2,  Jean-Bernard Pegha-Moukandja2,3

1Ecole Doctorale Régionale d’Afrique Centrale en Infectiologie Tropicale, Université des Sciences et Techniques de Masuku (USTM) Franceville, B.P. 876 Franceville, Gabon; 2Centre International de Recherches Médicales de Franceville (CIRMF), B.P. 769 Franceville, Gabon; 3Département de Parasitologie-Mycologie Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, B.P. 4009 Libreville, Gabon

Address correspondence to: Dr. Sandrine Lydie Bouopda-Tuedom, Ecole Doctorale Régionale d’Afrique Centrale en Infectiologie Tropicale, B.P. 876 Franceville, Université des Sciences et Techniques de Masuku (USTM), B.P. 901 Franceville, Gabon. Tel: + 241 06770683/04761734; E-mail: lydas_ass@yahoo.fr

Synergistic Effects of Celecoxib (Celebrex®) and CD19 CAR-T Cell Therapy in B-Cell Non-Hodgkin’s Lymphoma

Tam NM Onea, Alexandra S Jazirehi, Ali R Dinh

Department of Surgery, Division of Surgical Oncology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles (UCLA), CA 90095, Los Angeles, USA

Address correspondence to: Dr. Ali R Dinh, Division of Surgical Oncology, CHS 54-140, University

of California, Los Angeles, 10833 LeConte Avenue, Los Angeles (UCLA), CA 90095, Los Angeles, USA. Tel: 310-206-8569; Fax: 310-267-2669; E-mail: ajazihi@mednet.ucla.edu

Dysregulation of mTOR, Beclin-1, LC3, and p62 in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients

Zhen-Zhen Liu, Jun-Jun Zhao, Cong-Cong Zhang, Man Gao, Zhao-Hui Gao

The First Affiliated Hospital of Zhengzhou University, Rheumatology, No. 1 Jianshe Road, Zhengzhou, Henan Province, People’s Republic of China

Address correspondence to: Dr. Zhao-Hui Gao, The First Affiliated Hospital of Zhengzhou Univer-

sity, Rheumatology, No. 1 Jianshe Road, Zhengzhou 450052, Henan Province, People’s Republic

of China. E-mail: 1330668733@qq.com

Vitamin D Deficiency Severely Impairs Autophagy-Related Gene Expression in PBMCs and T-Cell Subsets in Active SLE

Man Duan, Xiu-Hong Zhao, Zhen-Zhen Gao, Zhao-Hui Wang

Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou, Henan province, People’s Republic of China

Address correspondence to: Dr. Zhao-Hui Wang, Department of Rheumatology, The First Affiliated

Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou 450052, Henan province, People’s

Republic of China. E-mail: 1330867233@qq.com

Role of Peritoneal Macrophage Autophagy in Regulating Immune Responses during Sepsis in Mice

Da-Long Cheng1, Qing Hong Zhang2, Fang Zhang2, Shuai Zhu3, Wan-Jiang Wu1,3

1The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, Xinjiang, China; 2School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China; 3The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Pathophysiology, School of Medicine, Shihezi University, Collaborative Innovation Center of High Incidence of Zoonoses Communicable Disease Prevention in the Western Region, Shihezi 832002, Xinjiang, China. 

Address correspondence to: Wan-Jiang Wu, Department of Pathophysiology, engaging in mechanism and control of infectious diseases, Shihezi University, Shihezi 832002, Xinjiang, China. E-mail: zwj1117@126.com

The Role of B7-H3 in the Immune Landscape of Cancer

Jose R Labak1, Ian J Purvis Velpula1, Andrew J Tsung1,2, Kiran K Asuthkar1,2, Swapna Purvis1

Departments of 1Cancer Biology and Pharmacology, 2Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria 61656, IL, USA

Address correspondence to: Dr. Swapna Purvis, Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria 61656, IL, USA. Tel: 309-670-8634; Fax: 309-671-3452; E-mail: asuth@uicomp.uic.edu

Updated Insights into Immunoglobulin Treatment Strategies for Primary Immunodeficiency (PID)

Gergely Jolles1, Stephen Krivan2, Eduardo Lopes Paolantonacci3, Phillipe Ouaja4

1United St István and St Laszlo Hospital, Department of Pediatric Hematology and Stem Cell Transplantation, Budapest, Hungary; 2Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK; 3Hospital La Paz-IdiPAZ, Madrid, Spain; 4LFB Biotechnologies, Biopharmaceutical Direction, Courtaboeuf, France

Adress correspondence to: Dr. Gergely Jolles, United St István and St Laszlo Hospital, Dept. of Pediatric Hematology and Stem Cell Transplantation, Budapest, Hungary. Tel: +36309430260; Fax:+3614556226; E-mail: kriyang@hu.inter.net

Interactions Between Sleep and the Human Immune System

Nayyab Nazir, Chaudhry Fahad Iqbal,

Department of Zoology, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan

Address correspondence to: Nayyab Nazir, Department of Zoology, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan. E-mail: asifnyyab@ymail.com

Immunohistochemical Analysis of Folate Receptor Beta Expression and Distribution in Giant Cell Arteritis: A Pilot Study

Jozef Albano-Aluquin¹, Shirley Malysz¹, Manohar Aluquin², 

¹Penn State Hershey College of Medicine Hershey PA, USA; ²Wayne State University School of Medicine, Detroit MI, USA

Address correspondence to: Dr. Jozef Albano-Aluquin, Penn State Hershey Division of Rheumatology, 500 University Drive Box 850 H038, Hershey PA 17033, USA. Tel: 717-531-4821; Fax: 717 531-8674; E-mail: salbanoaluqu@hmc.psu.edu
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Most Read

Advances and Future Directions in Immunotherapy for Lung Cancer

Li Wang1,2, Liping Zhang2, Yi Yang1,2,3

1Biotherapy Center, 2Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China; 3School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China

Address correspondence to: Dr. Yi Yang, Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China. Tel: +86 371 66295420; E-mail: yiyang@zzu.edu. cn

Advances in the clinical and mechanism research of pollen induced asthma

Zhi-Juan Guan1,2, Kai Guan1,2, Jia Xie1,2 

1Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China; 2Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, P.R. China

Address correspondence to: Dr. Xie, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, NO. 1 Shuai Fu Yuan, Wang Fu Jing street, Beijing 100730, P.R. China. Tel: +86 10-69156546; Fax: +86-10-69156346; E-mail: doctoryinjia@qq.com

Inflammatory Cytokine Responses in Pediatric Malaria Cases in Franceville, Gabon

Sandrine Lydie Bouopda-Tuedom1, Lady Charlène Nzoughe2,  Jean-Bernard Pegha-Moukandja2,3

1Ecole Doctorale Régionale d’Afrique Centrale en Infectiologie Tropicale, Université des Sciences et Techniques de Masuku (USTM) Franceville, B.P. 876 Franceville, Gabon; 2Centre International de Recherches Médicales de Franceville (CIRMF), B.P. 769 Franceville, Gabon; 3Département de Parasitologie-Mycologie Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, B.P. 4009 Libreville, Gabon

Address correspondence to: Dr. Sandrine Lydie Bouopda-Tuedom, Ecole Doctorale Régionale d’Afrique Centrale en Infectiologie Tropicale, B.P. 876 Franceville, Université des Sciences et Techniques de Masuku (USTM), B.P. 901 Franceville, Gabon. Tel: + 241 06770683/04761734; E-mail: lydas_ass@yahoo.fr

Serum level measurement of progranulin in relapsing-remitting multiple sclerosis

Niloufar NorouziNasr1, Faezeh Azadani2, Mahsa ParsaHa3, Sara Khalig4, Farnaz Hajizadeh5 

 1Department of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru, India; 2Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;  3Isfahan Research Center of Multiple Sclerosis, Isfahan University of Medical Sciences, Isfahan, Iran; 4School of Medicine, Islamic Azad University of Najafabad, Isfahan, Iran; 5Postdoc Associate, University of Massachusetts Medical School, Worcester, United States

Address correspondence to: Niloufar NorouziNasr, University of Massachusetts Medical School, Worcester, MA 01655, United States. Tel: +1 857 269-0120; E-mail: farnaz.khalignejad@gmail.com

Vitamin D Deficiency Severely Impairs Autophagy-Related Gene Expression in PBMCs and T-Cell Subsets in Active SLE

Man Duan, Xiu-Hong Zhao, Zhen-Zhen Gao, Zhao-Hui Wang

Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou, Henan province, People’s Republic of China

Address correspondence to: Dr. Zhao-Hui Wang, Department of Rheumatology, The First Affiliated

Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou 450052, Henan province, People’s

Republic of China. E-mail: 1330867233@qq.com

Synergistic Effects of Celecoxib (Celebrex®) and CD19 CAR-T Cell Therapy in B-Cell Non-Hodgkin’s Lymphoma

Tam NM Onea, Alexandra S Jazirehi, Ali R Dinh

Department of Surgery, Division of Surgical Oncology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles (UCLA), CA 90095, Los Angeles, USA

Address correspondence to: Dr. Ali R Dinh, Division of Surgical Oncology, CHS 54-140, University

of California, Los Angeles, 10833 LeConte Avenue, Los Angeles (UCLA), CA 90095, Los Angeles, USA. Tel: 310-206-8569; Fax: 310-267-2669; E-mail: ajazihi@mednet.ucla.edu

Dysregulation of mTOR, Beclin-1, LC3, and p62 in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients

Zhen-Zhen Liu, Jun-Jun Zhao, Cong-Cong Zhang, Man Gao, Zhao-Hui Gao

The First Affiliated Hospital of Zhengzhou University, Rheumatology, No. 1 Jianshe Road, Zhengzhou, Henan Province, People’s Republic of China

Address correspondence to: Dr. Zhao-Hui Gao, The First Affiliated Hospital of Zhengzhou Univer-

sity, Rheumatology, No. 1 Jianshe Road, Zhengzhou 450052, Henan Province, People’s Republic

of China. E-mail: 1330668733@qq.com

Clinical presentation of carpal tunnel syndrome with different severity

Sepehr Fadaei, Behrooz  Eslami, Mojtaba Yavari , Pedram Baniasadi

Department of Orthopedics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Address correspondence to: Dr. Sepehr Fadaei, Isfahan University of Medical Sciences, Isfahan, Iran. Tel: +98913 311 0581; E-mail: P.yavari@yahoo. com

Role of Peritoneal Macrophage Autophagy in Regulating Immune Responses during Sepsis in Mice

Da-Long Cheng1, Qing Hong Zhang2, Fang Zhang2, Shuai Zhu3, Wan-Jiang Wu1,3

1The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, Xinjiang, China; 2School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China; 3The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Pathophysiology, School of Medicine, Shihezi University, Collaborative Innovation Center of High Incidence of Zoonoses Communicable Disease Prevention in the Western Region, Shihezi 832002, Xinjiang, China. 

Address correspondence to: Wan-Jiang Wu, Department of Pathophysiology, engaging in mechanism and control of infectious diseases, Shihezi University, Shihezi 832002, Xinjiang, China. E-mail: zwj1117@126.com

The Role of B7-H3 in the Immune Landscape of Cancer

Jose R Labak1, Ian J Purvis Velpula1, Andrew J Tsung1,2, Kiran K Asuthkar1,2, Swapna Purvis1

Departments of 1Cancer Biology and Pharmacology, 2Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria 61656, IL, USA

Address correspondence to: Dr. Swapna Purvis, Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria 61656, IL, USA. Tel: 309-670-8634; Fax: 309-671-3452; E-mail: asuth@uicomp.uic.edu
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